Version 5.4
Mus musculus Gene: Magel2
Summary
InnateDB Gene IDBG-190599.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Magel2
Gene Name melanoma antigen, family L, 2
Synonyms Mage-l2; NDNL1; nM15; ns7
Species Mus musculus
Ensembl Gene ENSMUSG00000056972
Encoded Proteins
IDBP-190601
melanoma antigen, family L, 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000254585:
Prader-Willi syndrome (PWS) is caused by the loss of expression of imprinted genes in chromosome 15q11-q13 region. Affected individuals exhibit neonatal hypotonia, developmental delay, and childhood-onset obesity. Necdin (NDN), a gene involved in the terminal differentiation of neurons, localizes to this region of the genome and has been implicated as one of the genes responsible for the etiology of PWS. This gene is structurally similar to NDN, is also localized to the PWS chromosomal region, and is paternally imprinted, suggesting a possible role for it in PWS. [provided by RefSeq, Oct 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:62376979-62381640
Strand Forward strand
Band C
Transcripts
ENSMUST00000080403 ENSMUSP00000079265
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
Biological Process
GO:0034314 Arp2/3 complex-mediated actin nucleation
GO:0042147 retrograde transport, endosome to Golgi
GO:0070534 protein K63-linked ubiquitination
Cellular Component
GO:0005768 endosome
GO:0030904 retromer complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000254585
View Gene Order
ENSBTAG00000045998
Not yet available
Cross-References
SwissProt Q9QZ04
TrEMBL F8WIA8 Q6IR13 Q9JIN9
UniProt Splice Variant
Entrez Gene 27385
UniGene Mm.402708 Mm.45207
RefSeq NM_013779
OMIM
CCDS CCDS52264
HPRD
IMGT
MGI ID MGI:1351648
MGI Symbol Magel2
EMBL AC156555 AF212306 AJ243608 BC054763 BC071222
GenPept AAF97424 AAH54763 AAH71222 CAB62395
RNA Seq Atlas 27385

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca