InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Magel2

Summary

InnateDB Protein

IDBP-190601.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Magel2

Protein Name

melanoma antigen, family L, 2

Synonyms

Mage-l2; NDNL1; nM15; ns7;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000079265

InnateDB Gene

IDBG-190599 (Magel2)

Protein Structure

UniProt Annotation

Function

Probably enhances ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases, possibly through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Acts as a regulator of retrograde transport via its interaction with VPS35. Recruited to retromer-containing endosomes and promotes the formation of 'Lys- 63'-linked polyubiquitin chains at 'Lys-220' of WASH1 together with TRIM27, leading to promote endosomal F-actin assembly (By similarity). {ECO:0000250}.

Subcellular Localization

Early endosome. Note=Recruited to retromer- containing endosomes via interaction with VPS35. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed predominantly in late development stages and adult brain. {ECO:0000269PubMed:10915770}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding

Biological Process

GO:0034314	Arp2/3 complex-mediated actin nucleation
GO:0042147	retrograde transport, endosome to Golgi
GO:0070534	protein K63-linked ubiquitination

Cellular Component

GO:0005768	endosome
GO:0030904	retromer complex

Protein Structure and Domains

PDB ID

MGI:1351648

InterPro

IPR002190 MAGE protein

PFAM

PF01454

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

MGI ID

MGI Symbol

OMIM

CCDS

HPRD

IMGT

EMBL

AC156555 AF212306 AJ243608 BC054763 BC071222

GenPept

AAF97424 AAH54763 AAH71222 CAB62395

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1)

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca