InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Yars

Summary

InnateDB Gene

IDBG-190620.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Yars

Gene Name

tyrosyl-tRNA synthetase

Synonyms

AL024047; AU018965

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028811

Encoded Proteins

IDBP-269560

tyrosyl-tRNA synthetase

IDBP-540067

tyrosyl-tRNA synthetase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134684:
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Tyrosyl-tRNA synthetase belongs to the class I tRNA synthetase family. Cytokine activities have also been observed for the human tyrosyl-tRNA synthetase, after it is split into two parts, an N-terminal fragment that harbors the catalytic site and a C-terminal fragment found only in the mammalian enzyme. The N-terminal fragment is an interleukin-8-like cytokine, whereas the released C-terminal fragment is an EMAP II-like cytokine. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:129189760-129219607

Strand

Forward strand

Band

D2.2

Transcripts

ENSMUST00000106054	ENSMUSP00000101669
ENSMUST00000128287
ENSMUST00000133992	ENSMUSP00000118512
ENSMUST00000140708
ENSMUST00000146106
ENSMUST00000148619
ENSMUST00000137591
ENSMUST00000147248

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000049	tRNA binding
GO:0000166	nucleotide binding
GO:0004812	aminoacyl-tRNA ligase activity
GO:0004831	tyrosine-tRNA ligase activity
GO:0005524	ATP binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006418	tRNA aminoacylation for protein translation
GO:0006437	tyrosyl-tRNA aminoacylation
GO:0008150	biological_process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000134684

View Gene Order

ENSBTAG00000018065

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu00970

Aminoacyl-tRNA biosynthesis pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_15306

Cytosolic tRNA aminoacylation pathway

REACT_15482

tRNA Aminoacylation pathway

REACT_71

Gene Expression pathway

KEGG

hsa00970

Aminoacyl-tRNA biosynthesis pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.145488 Mm.415577

RefSeq

NM_134151

OMIM

CCDS

CCDS18685

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas