Version 5.4
Mus musculus Gene: Acp2
Summary
InnateDB Gene IDBG-190861.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Acp2
Gene Name acid phosphatase 2, lysosomal
Synonyms Acp-2; LAP
Species Mus musculus
Ensembl Gene ENSMUSG00000002103
Encoded Proteins
IDBP-190865
acid phosphatase 2, lysosomal
IDBP-535008
acid phosphatase 2, lysosomal
IDBP-539892
acid phosphatase 2, lysosomal
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134575:
This gene encodes the beta subunit of lysosomal acid phosphatase (LAP). LAP is chemically and genetically distinct from red cell acid phosphatase. The encoded protein belongs to a family of distinct isoenzymes which hydrolyze orthophosphoric monoesters to alcohol and phosphate. Mutations in this gene or in the related alpha subunit gene cause acid phosphatase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Aug 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:91202885-91214098
Strand Forward strand
Band E1
Transcripts
ENSMUST00000002172 ENSMUSP00000002172
ENSMUST00000150403 ENSMUSP00000119144
ENSMUST00000155418 ENSMUSP00000116030
ENSMUST00000124131
ENSMUST00000127643
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003993 acid phosphatase activity
Biological Process
GO:0001501 skeletal system development
GO:0007040 lysosome organization
GO:0016311 dephosphorylation
Cellular Component
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043202 lysosomal lumen
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000134575
View Gene Order
ENSBTAG00000021002
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu00740
Riboflavin metabolism pathway
mmu04142
Lysosome pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00740
Riboflavin metabolism pathway
hsa04142
Lysosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.45570
RefSeq NM_007387
OMIM
CCDS CCDS16427
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca