InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Wwp2

Summary

InnateDB Gene

IDBG-190874.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Wwp2

Gene Name

WW domain containing E3 ubiquitin protein ligase 2

Synonyms

1300010O06Rik; AA690238; AIP2; AW554328

Species

Mus musculus

Ensembl Gene

ENSMUSG00000031930

Encoded Proteins

IDBP-622302

WW domain containing E3 ubiquitin protein ligase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198373:
This gene encodes a member of the Nedd4 family of E3 ligases, which play an important role in protein ubiquitination. The encoded protein contains four WW domains and may play a role in multiple processes including chondrogenesis and the regulation of oncogenic signaling pathways via interactions with Smad proteins and the tumor suppressor PTEN. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 10. [provided by RefSeq, Jul 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:107436398-107558594

Strand

Forward strand

Band

Transcripts

ENSMUST00000166615

ENSMUSP00000132224

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 48 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	48 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001085	RNA polymerase II transcription factor binding
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0016874	ligase activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0010629	negative regulation of gene expression
GO:0016567	protein ubiquitination
GO:0032410	negative regulation of transporter activity
GO:0034765	regulation of ion transmembrane transport
GO:0042391	regulation of membrane potential
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045892	negative regulation of transcription, DNA-templated
GO:0051224	negative regulation of protein transport
GO:0051865	protein autoubiquitination
GO:0070534	protein K63-linked ubiquitination
GO:1901016	regulation of potassium ion transmembrane transporter activity

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016020	membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000198373

View Gene Order

ENSBTAG00000018421

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu04120

Ubiquitin mediated proteolysis pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa04120

Ubiquitin mediated proteolysis pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.390058

RefSeq

NM_025830 XM_006531299 XM_006531300 XM_006531302

OMIM

CCDS

CCDS40467

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas