InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Wwp2

Summary

InnateDB Protein

IDBP-622302.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Wwp2

Protein Name

WW domain containing E3 ubiquitin protein ligase 2

Synonyms

1300010O06Rik; AA690238; AIP2; AW554328;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000132224

InnateDB Gene

IDBG-190874 (Wwp2)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by 'Lys-63'-linked conjugation and promotes it to proteasomal degradation; regulates POU5F1 protein level during differentiation of embryonal carcinoma cells (ECCs) but not in undifferentiated ECCs and embryonic stem cells (ESCs). Ubiquitinates EGR2 and promotes it to proteasomal degradation; in T-cells the ubiquitination inhibits activation-induced cell death. Ubiquitinates SLC11A2; the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal degradation. {ECO:0000269PubMed:17526739, ECO:0000269PubMed:18776082, ECO:0000269PubMed:19651900, ECO:0000269PubMed:19997087}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 48 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	48 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001085	RNA polymerase II transcription factor binding
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0016874	ligase activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0010629	negative regulation of gene expression
GO:0016567	protein ubiquitination
GO:0032410	negative regulation of transporter activity
GO:0034765	regulation of ion transmembrane transport
GO:0042391	regulation of membrane potential
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045892	negative regulation of transcription, DNA-templated
GO:0051224	negative regulation of protein transport
GO:0051865	protein autoubiquitination
GO:0070534	protein K63-linked ubiquitination
GO:1901016	regulation of potassium ion transmembrane transporter activity