InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Tead4

Summary

InnateDB Gene

IDBG-190898.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tead4

Gene Name

TEA domain family member 4

Synonyms

ETFR-2; Etfr2; FR-19; Rtef1; Tcf13r1; TEAD-4; TEF-3; Tef3; Tefr; Tefr1; Tefr1a

Species

Mus musculus

Ensembl Gene

ENSMUSG00000030353

Encoded Proteins

IDBP-190900

TEA domain family member 4

IDBP-256581

TEA domain family member 4

IDBP-532587

TEA domain family member 4

IDBP-534247

TEA domain family member 4

IDBP-534650

TEA domain family member 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is preferentially expressed in the skeletal muscle, and binds to the M-CAT regulatory element found in promoters of muscle-specific genes to direct their gene expression. This factor may play a role in the embryonic development of skeletal muscle. Alternatively spliced transcripts encoding distinct isoforms, which are translated through the use of a non-AUG (AUU) initiation codon, have been described for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:128224288-128300823

Strand

Reverse strand

Band

Transcripts

ENSMUST00000006311	ENSMUSP00000006311
ENSMUST00000112157	ENSMUSP00000107784
ENSMUST00000130454	ENSMUSP00000118083
ENSMUST00000133118	ENSMUSP00000120941
ENSMUST00000143004	ENSMUSP00000118606

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity

Biological Process

GO:0001701	in utero embryonic development
GO:0001708	cell fate specification
GO:0001825	blastocyst formation
GO:0001830	trophectodermal cell fate commitment
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007566	embryo implantation
GO:0035329	hippo signaling
GO:0045944	positive regulation of transcription from RNA polymerase II promoter