InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tead4

Summary

InnateDB Protein

IDBP-256581.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tead4

Protein Name

TEA domain family member 4

Synonyms

ETFR-2; Etfr2; FR-19; Rtef1; Tcf13r1; TEAD-4; TEF-3; Tef3; Tefr; Tefr1; Tefr1a;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000107784

InnateDB Gene

IDBG-190898 (Tead4)

Protein Structure

UniProt Annotation

Function

Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif (By similarity). Might play a role in the embryonic development of skeletal muscle. {ECO:0000250}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Preferentially expressed in lung and in skeletal muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity

Biological Process

GO:0001701	in utero embryonic development
GO:0001708	cell fate specification
GO:0001825	blastocyst formation
GO:0001830	trophectodermal cell fate commitment
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007566	embryo implantation
GO:0035329	hippo signaling
GO:0045944	positive regulation of transcription from RNA polymerase II promoter