Version 5.4
Mus musculus Gene: Atp1b2
Summary
InnateDB Gene IDBG-191112.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Atp1b2
Gene Name ATPase, Na+/K+ transporting, beta 2 polypeptide
Synonyms Amog; Atpb-2
Species Mus musculus
Ensembl Gene ENSMUSG00000041329
Encoded Proteins
IDBP-191114
ATPase, Na+/K+ transporting, beta 2 polypeptide
IDBP-541725
ATPase, Na+/K+ transporting, beta 2 polypeptide
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000129244:
The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 2 subunit. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:69599736-69605942
Strand Reverse strand
Band B3
Transcripts
ENSMUST00000047889 ENSMUSP00000047353
ENSMUST00000130394
ENSMUST00000138694 ENSMUSP00000116290
ENSMUST00000144425
ENSMUST00000153198
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006813 potassium ion transport
GO:0006814 sodium ion transport
GO:0007155 cell adhesion
Cellular Component
GO:0005737 cytoplasm
GO:0005890 sodium:potassium-exchanging ATPase complex
GO:0016324 apical plasma membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000129244
View Gene Order
ENSBTAG00000013680
Not yet available
Pathways
NETPATH
REACTOME
REACT_224553
Hemostasis pathway
REACT_225233
Cell surface interactions at the vascular wall pathway
REACT_211508
Basigin interactions pathway
REACT_262350
Ion channel transport pathway
REACT_253400
Transmembrane transport of small molecules pathway
REACT_250224
Ion transport by P-type ATPases pathway
KEGG
mmu04260
Cardiac muscle contraction pathway
mmu04960
Aldosterone-regulated sodium reabsorption pathway
mmu04971
Gastric acid secretion pathway
mmu04974
Protein digestion and absorption pathway
mmu04973
Carbohydrate digestion and absorption pathway
mmu04970
Salivary secretion pathway
mmu04976
Bile secretion pathway
mmu04964
Proximal tubule bicarbonate reclamation pathway
mmu04972
Pancreatic secretion pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_12560
Basigin interactions pathway
REACT_12051
Cell surface interactions at the vascular wall pathway
REACT_25149
Ion transport by P-type ATPases pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_25300
Ion channel transport pathway
REACT_604
Hemostasis pathway
KEGG
hsa04260
Cardiac muscle contraction pathway
hsa04960
Aldosterone-regulated sodium reabsorption pathway
hsa04964
Proximal tubule bicarbonate reclamation pathway
hsa04971
Gastric acid secretion pathway
hsa04972
Pancreatic secretion pathway
hsa04970
Salivary secretion pathway
hsa04976
Bile secretion pathway
hsa04974
Protein digestion and absorption pathway
hsa04973
Carbohydrate digestion and absorption pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.235204 Mm.427142
RefSeq NM_013415
OMIM
CCDS CCDS24898
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca