Version 5.4
Mus musculus Gene: Srgap2
Summary
InnateDB Gene IDBG-191143.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Srgap2
Gene Name SLIT-ROBO Rho GTPase activating protein 2
Synonyms 9930124L22Rik; AI448945; FBP2; Fnbp2; srGAP3
Species Mus musculus
Ensembl Gene ENSMUSG00000026425
Encoded Proteins
IDBP-191147
SLIT-ROBO Rho GTPase activating protein 2
IDBP-787837
SLIT-ROBO Rho GTPase activating protein 2
IDBP-787840
SLIT-ROBO Rho GTPase activating protein 2
IDBP-787843
SLIT-ROBO Rho GTPase activating protein 2
IDBP-787845
SLIT-ROBO Rho GTPase activating protein 2
IDBP-787848
SLIT-ROBO Rho GTPase activating protein 2
IDBP-787849
SLIT-ROBO Rho GTPase activating protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog null:
This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. The encoded protein stimulates GTPase activity of Rac1, and plays a role in cortical neuron development. This locus has several paralogous loci on human chromosome 1, resulting from segmental duplication. While this locus itself is conserved among various species, the paralogs are found only in the genus Homo, and not in the genomes of non-human great apes. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Dec 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:131285251-131527352
Strand Reverse strand
Band E4
Transcripts
ENSMUST00000097588 ENSMUSP00000095195
ENSMUST00000187042 ENSMUSP00000140927
ENSMUST00000190336
ENSMUST00000186543 ENSMUSP00000139405
ENSMUST00000189892
ENSMUST00000188770 ENSMUSP00000140910
ENSMUST00000188604
ENSMUST00000185596 ENSMUSP00000141140
ENSMUST00000188437
ENSMUST00000189893
ENSMUST00000185445 ENSMUSP00000140787
ENSMUST00000187273 ENSMUSP00000139462
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0030675 Rac GTPase activator activity
GO:0042803 protein homodimerization activity
GO:0048365 Rac GTPase binding
Biological Process
GO:0007165 signal transduction
GO:0021816 extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration
GO:0032855 positive regulation of Rac GTPase activity
GO:0046847 filopodium assembly
GO:0048812 neuron projection morphogenesis
GO:0051014 actin filament severing
GO:0060996 dendritic spine development
GO:2001223 negative regulation of neuron migration
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005743 mitochondrial inner membrane
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0014069 postsynaptic density
GO:0030027 lamellipodium
GO:0030054 cell junction
GO:0044327 dendritic spine head
GO:0045211 postsynaptic membrane
GO:0045335 phagocytic vesicle
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
null
View Gene Order
Pathways
NETPATH
REACTOME
KEGG
mmu04360
Axon guidance pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001081011 XM_006529134 XM_006529135 XM_006529138
OMIM
CCDS CCDS48355
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca