InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Srgap2

Summary

InnateDB Protein

IDBP-191147.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Srgap2

Protein Name

SLIT-ROBO Rho GTPase activating protein 2

Synonyms

9930124L22Rik; AI448945; FBP2; Fnbp2; srGAP3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000095195

InnateDB Gene

IDBG-191143 (Srgap2)

Protein Structure

UniProt Annotation

Function

RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral cortex. May play a role for cognition, learning and memory. In non-neuronal cells, it may also play a role in cell migration by regulating the formation of lamellipodia and filopodia. {ECO:0000269PubMed:19737524, ECO:0000269PubMed:22559944}.

Subcellular Localization

Cell membrane {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse, postsynaptic cell membrane. Cell projection, lamellipodium {ECO:0000250}. Cytoplasmic vesicle, phagosome. Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Recruited to actin-rich phagosomes during phagocytosis. Translocates from nucleus to cytoplasm during development (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0030675	Rac GTPase activator activity
GO:0042803	protein homodimerization activity
GO:0048365	Rac GTPase binding

Biological Process

GO:0007165	signal transduction
GO:0021816	extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration
GO:0032855	positive regulation of Rac GTPase activity
GO:0046847	filopodium assembly
GO:0048812	neuron projection morphogenesis
GO:0051014	actin filament severing
GO:0060996	dendritic spine development
GO:2001223	negative regulation of neuron migration

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005743	mitochondrial inner membrane
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0014069	postsynaptic density
GO:0030027	lamellipodium
GO:0030054	cell junction
GO:0044327	dendritic spine head
GO:0045211	postsynaptic membrane
GO:0045335	phagocytic vesicle

Protein Structure and Domains

PDB ID

MGI:109605

InterPro

IPR000198 Rho GTPase-activating protein domain
IPR001060 FCH domain
IPR001452 SH3 domain
IPR008936 Rho GTPase activation protein
IPR011511 Variant SH3 domain

PFAM

PF00620
PF00611
PF00018
PF14604
PF07653

PRINTS

PR00452

PIRSF

SMART

SM00324
SM00055
SM00326

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt