Version 5.4
Mus musculus Gene: Mcee
Summary
InnateDB Gene IDBG-191163.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mcee
Gene Name methylmalonyl CoA epimerase
Synonyms 1110007A04Rik
Species Mus musculus
Ensembl Gene ENSMUSG00000033429
Encoded Proteins
IDBP-191165
methylmalonyl CoA epimerase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000124370:
The product of this gene catalyzes the interconversion of D- and L-methylmalonyl-CoA during the degradation of branched chain amino acids. odd chain-length fatty acids, and other metabolites. Mutations in this gene result in methylmalonyl-CoA epimerase deficiency, which is presented as mild to moderate methylmalonic aciduria. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:64392645-64412121
Strand Forward strand
Band C
Transcripts
ENSMUST00000037205 ENSMUSP00000047855
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004493 methylmalonyl-CoA epimerase activity
GO:0046872 metal ion binding
Biological Process
GO:0046491 L-methylmalonyl-CoA metabolic process
Cellular Component
GO:0005739 mitochondrion
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000124370
View Gene Order
ENSBTAG00000035247
Not yet available
Pathways
NETPATH
REACTOME
REACT_256522
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_233858
Mitochondrial Fatty Acid Beta-Oxidation pathway
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_253750
Propionyl-CoA catabolism pathway
KEGG
mmu00280
Valine, leucine and isoleucine degradation pathway
mmu00640
Propanoate metabolism pathway
mmu00630
Glyoxylate and dicarboxylate metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_993
Propionyl-CoA catabolism pathway
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_1473
Mitochondrial Fatty Acid Beta-Oxidation pathway
REACT_111217
Metabolism pathway
REACT_208669
Mitochondrial Fatty Acid Beta-Oxidation pathway
REACT_213207
Propionyl-CoA catabolism pathway
REACT_219933
Metabolism of lipids and lipoproteins pathway
REACT_219139
Metabolism pathway
REACT_226458
Fatty acid, triacylglycerol, and ketone body metabolism pathway
KEGG
hsa00280
Valine, leucine and isoleucine degradation pathway
hsa00640
Propanoate metabolism pathway
hsa00630
Glyoxylate and dicarboxylate metabolism pathway
INOH
INOH website
Propanoate metabolism pathway
PID NCI
Cross-References
SwissProt Q9D1I5
TrEMBL
UniProt Splice Variant
Entrez Gene 73724
UniGene
RefSeq NM_028626
OMIM
CCDS CCDS21334
HPRD
IMGT
MGI ID MGI:1920974
MGI Symbol Mcee
EMBL AK003511 BC038157
GenPept AAH38157 BAB22828
RNA Seq Atlas 73724

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca