Version 5.4
Homo sapiens Gene: MCEE
Summary
InnateDB Gene IDBG-55871.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MCEE
Gene Name methylmalonyl CoA epimerase
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000124370
Encoded Proteins
IDBP-55873
methylmalonyl CoA epimerase
IDBP-378959
methylmalonyl CoA epimerase
IDBP-603717
methylmalonyl CoA epimerase
IDBP-592643
methylmalonyl CoA epimerase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The product of this gene catalyzes the interconversion of D- and L-methylmalonyl-CoA during the degradation of branched chain amino acids. odd chain-length fatty acids, and other metabolites. Mutations in this gene result in methylmalonyl-CoA epimerase deficiency, which is presented as mild to moderate methylmalonic aciduria. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:71109684-71130239
Strand Reverse strand
Band p13.3
Transcripts
ENST00000244217 ENSP00000244217
ENST00000413592 ENSP00000391140
ENST00000462609
ENST00000486135 ENSP00000441569
ENST00000494660 ENSP00000437361
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004493 methylmalonyl-CoA epimerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006635 fatty acid beta-oxidation
GO:0019626 short-chain fatty acid catabolic process
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
GO:0046491 L-methylmalonyl-CoA metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000033429
View Gene Order
ENSBTAG00000035247
Not yet available
Pathways
NETPATH
REACTOME
REACT_993
Propionyl-CoA catabolism pathway
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_1473
Mitochondrial Fatty Acid Beta-Oxidation pathway
REACT_111217
Metabolism pathway
KEGG
hsa00280
Valine, leucine and isoleucine degradation pathway
hsa00640
Propanoate metabolism pathway
hsa00630
Glyoxylate and dicarboxylate metabolism pathway
INOH
INOH website
Propanoate metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.691217
RefSeq NM_032601 XM_005264613
HUGO
OMIM
CCDS CCDS1915
HPRD 12229
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca