InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: F3

Summary

InnateDB Gene

IDBG-191176.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gene Name

coagulation factor III

Synonyms

AA409063; CD142; Cf-3; Cf3; TF

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028128

Encoded Proteins

IDBP-191178

coagulation factor III

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000117525:
This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:121723537-121735052

Strand

Forward strand

Band

Transcripts

ENSMUST00000029771

ENSMUSP00000029771

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0005515	protein binding
GO:0005543	phospholipid binding

Biological Process

GO:0001938	positive regulation of endothelial cell proliferation
GO:0002541	activation of plasma proteins involved in acute inflammatory response
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007596	blood coagulation
GO:0010641	positive regulation of platelet-derived growth factor receptor signaling pathway
GO:0045766	positive regulation of angiogenesis
GO:0051897	positive regulation of protein kinase B signaling

Cellular Component

GO:0005615	extracellular space
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0031012	extracellular matrix
GO:0070062	extracellular vesicular exosome