InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: F3

Summary

InnateDB Gene

IDBG-100378.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gene Name

coagulation factor III (thromboplastin, tissue factor)

Synonyms

CD142; TF; TFA

Species

Homo sapiens

Ensembl Gene

ENSG00000117525

Encoded Proteins

IDBP-100380

coagulation factor III (thromboplastin, tissue factor)

IDBP-100382

coagulation factor III (thromboplastin, tissue factor)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:94529225-94541800

Strand

Reverse strand

Band

p21.3

Transcripts

ENST00000334047	ENSP00000334145
ENST00000370207	ENSP00000359226
ENST00000478217
ENST00000480356

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0005515	protein binding
GO:0005543	phospholipid binding

Biological Process

GO:0001938	positive regulation of endothelial cell proliferation
GO:0002541	activation of plasma proteins involved in acute inflammatory response
GO:0002543	activation of blood coagulation via clotting cascade
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007596	blood coagulation
GO:0007598	blood coagulation, extrinsic pathway
GO:0010641	positive regulation of platelet-derived growth factor receptor signaling pathway
GO:0030335	positive regulation of cell migration
GO:0045766	positive regulation of angiogenesis
GO:0050927	positive regulation of positive chemotaxis
GO:0051897	positive regulation of protein kinase B signaling

Cellular Component

GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0031012	extracellular matrix
GO:0031233	intrinsic to external side of plasma membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000028128

View Gene Order

ENSBTAG00000007101

Not yet available

Pathways

NETPATH

REACTOME

REACT_1573

Extrinsic Pathway pathway

REACT_2051

Formation of Fibrin Clot (Clotting Cascade) pathway

REACT_604

Hemostasis pathway

KEGG

hsa04610

Complement and coagulation cascades pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.609746 Hs.62192 Hs.623540

RefSeq

NM_001178096 NM_001993

HUGO

OMIM

CCDS

CCDS53345 CCDS750

HPRD

00603

IMGT

EMBL

GenPept

RNA Seq Atlas