Version 5.4
Mus musculus Gene: Adrbk2
Summary
InnateDB Gene IDBG-191440.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Adrbk2
Gene Name adrenergic receptor kinase, beta 2
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000042249
Encoded Proteins
IDBP-191442
adrenergic receptor kinase, beta 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100077:
The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the beta adrenergic receptor kinase 2 has 85% amino acid similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95% similarity. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function. [provided by RefSeq, Jul 2008]
The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the beta adrenergic receptor kinase 2 has 85%% amino acid similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95%% similarity. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:112910478-113015514
Strand Reverse strand
Band F
Transcripts
ENSMUST00000065167 ENSMUSP00000070445
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004703 G-protein coupled receptor kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0047696 beta-adrenergic receptor kinase activity
Biological Process
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0031623 receptor internalization
GO:0038032 termination of G-protein coupled receptor signaling pathway
Cellular Component
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000100077
View Gene Order
ENSBTAG00000000005
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04740
Olfactory transduction pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_16
IL4 pathway
REACTOME
KEGG
hsa04740
Olfactory transduction pathway
hsa04144
Endocytosis pathway
hsa04062
Chemokine signaling pathway pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
PID NCI
thrombin_par1_pathway
PAR1-mediated thrombin signaling events
Cross-References
SwissProt Q3UYH7
TrEMBL
UniProt Splice Variant
Entrez Gene 320129
UniGene Mm.285619 Mm.396291 Mm.400992
RefSeq NM_001285806 NM_177078
OMIM
CCDS CCDS19545
HPRD
IMGT
MGI ID MGI:87941
MGI Symbol Adrbk2
EMBL AC107631 AK134672
GenPept BAE22235
RNA Seq Atlas 320129

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca