InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ADRBK2

Summary

InnateDB Gene

IDBG-635734.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADRBK2

Gene Name

Beta-adrenergic receptor kinase 2

Synonyms

GRK3

Species

Bos taurus

Ensembl Gene

ENSBTAG00000000005

Encoded Proteins

IDBP-687613

Beta-adrenergic receptor kinase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100077:
The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the beta adrenergic receptor kinase 2 has 85% amino acid similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95% similarity. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function. [provided by RefSeq, Jul 2008]
The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the beta adrenergic receptor kinase 2 has 85%% amino acid similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95%% similarity. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:67669019-67758720

Strand

Forward strand

Band

Transcripts

ENSBTAT00000000005

ENSBTAP00000000005

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004703	G-protein coupled receptor kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0047696	beta-adrenergic receptor kinase activity

Biological Process

GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0016310	phosphorylation
GO:0031623	receptor internalization
GO:0038032	termination of G-protein coupled receptor signaling pathway