Version 5.4
Mus musculus Gene: Senp3
Summary
InnateDB Gene IDBG-191561.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Senp3
Gene Name SUMO/sentrin specific peptidase 3
Synonyms AA408656; Smt3ip; Smt3ip1
Species Mus musculus
Ensembl Gene ENSMUSG00000005204
Encoded Proteins
IDBP-191563
SUMO/sentrin specific peptidase 3
IDBP-191567
SUMO/sentrin specific peptidase 3
IDBP-538304
SUMO/sentrin specific peptidase 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000161956:
The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP3, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]).[supplied by OMIM, Jun 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:69673115-69682084
Strand Reverse strand
Band B3
Transcripts
ENSMUST00000005336 ENSMUSP00000005336
ENSMUST00000066760 ENSMUSP00000066581
ENSMUST00000123084
ENSMUST00000153516
ENSMUST00000134942 ENSMUSP00000114791
ENSMUST00000142206
ENSMUST00000135372
ENSMUST00000130440
ENSMUST00000128355
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 3 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 29 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004843 ubiquitin-specific protease activity
GO:0005515 protein binding
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0019538 protein metabolic process
Cellular Component
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0071339 MLL1 complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000161956
View Gene Order
ENSBTAG00000000131
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.284592
RefSeq NM_001163571 NM_030702
OMIM
CCDS CCDS24905
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca