Version 5.4
Mus musculus Gene: Iscu
Summary
InnateDB Gene IDBG-191860.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Iscu
Gene Name IscU iron-sulfur cluster scaffold homolog (E. coli)
Synonyms 2310020H20Rik; AA407971; Nifu; Nifun
Species Mus musculus
Ensembl Gene ENSMUSG00000025825
Encoded Proteins
IDBP-191862
IscU iron-sulfur cluster scaffold homolog (E. coli)
IDBP-256277
IscU iron-sulfur cluster scaffold homolog (E. coli)
IDBP-256279
IscU iron-sulfur cluster scaffold homolog (E. coli)
IDBP-541854
IscU iron-sulfur cluster scaffold homolog (E. coli)
IDBP-537137
IscU iron-sulfur cluster scaffold homolog (E. coli)
IDBP-533592
IscU iron-sulfur cluster scaffold homolog (E. coli)
IDBP-537465
IscU iron-sulfur cluster scaffold homolog (E. coli)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136003:
Iron-sulfur (Fe-S) clusters are necessary for several mitochondrial enzymes and other subcellular compartment proteins. They contain sulfur and iron, and are created via several steps that include cysteine desulfurases, iron donors, chaperones, and scaffold proteins. This gene encodes the two isomeric forms, ISCU1 and ISCU2, of the Fe-S cluster scaffold protein. Mutations in this gene have been found in patients with myopathy with severe exercise intolerance and myoglobinuria. [provided by RefSeq, Jul 2008]
Iron-sulfur (Fe-S) clusters are necessary for several mitochondrial enzymes and other subcellular compartment proteins. They contain sulfur and iron, and are created via several steps that include cysteine desulfurases, iron donors, chaperones, and scaffold proteins. This gene encodes the two isomeric forms, ISCU1 and ISCU2, of the Fe-S cluster scaffold protein. Mutations in this gene have been found in patients with myopathy with severe exercise intolerance and myoglobinuria. A pseudogene of this gene is present on chromosome 1. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:113772748-113778288
Strand Forward strand
Band F
Transcripts
ENSMUST00000026937 ENSMUSP00000026937
ENSMUST00000112312 ENSMUSP00000107931
ENSMUST00000112311 ENSMUSP00000107930
ENSMUST00000123616 ENSMUSP00000117973
ENSMUST00000145778 ENSMUSP00000117053
ENSMUST00000134881 ENSMUSP00000120553
ENSMUST00000145592 ENSMUSP00000123237
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0032947 protein complex scaffold
GO:0051536 iron-sulfur cluster binding
Biological Process
GO:0016226 iron-sulfur cluster assembly
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000136003
View Gene Order
ENSBTAG00000011787
Not yet available
Pathways
NETPATH
REACTOME
REACT_188937
Metabolism pathway
REACT_199053
Mitochondrial iron-sulfur cluster biogenesis pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_025526
OMIM
CCDS CCDS19553
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca