Version 5.4
Bos taurus Gene: ISCU
Summary
InnateDB Gene IDBG-635612.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ISCU
Gene Name iron-sulfur cluster assembly enzyme ISCU, mitochondrial
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000011787
Encoded Proteins
IDBP-687458
iron-sulfur cluster assembly enzyme ISCU, mitochondrial
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136003:
Iron-sulfur (Fe-S) clusters are necessary for several mitochondrial enzymes and other subcellular compartment proteins. They contain sulfur and iron, and are created via several steps that include cysteine desulfurases, iron donors, chaperones, and scaffold proteins. This gene encodes the two isomeric forms, ISCU1 and ISCU2, of the Fe-S cluster scaffold protein. Mutations in this gene have been found in patients with myopathy with severe exercise intolerance and myoglobinuria. [provided by RefSeq, Jul 2008]
Iron-sulfur (Fe-S) clusters are necessary for several mitochondrial enzymes and other subcellular compartment proteins. They contain sulfur and iron, and are created via several steps that include cysteine desulfurases, iron donors, chaperones, and scaffold proteins. This gene encodes the two isomeric forms, ISCU1 and ISCU2, of the Fe-S cluster scaffold protein. Mutations in this gene have been found in patients with myopathy with severe exercise intolerance and myoglobinuria. A pseudogene of this gene is present on chromosome 1. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:66685452-66691553
Strand Forward strand
Band
Transcripts
ENSBTAT00000015648 ENSBTAP00000015648
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0032947 protein complex scaffold
GO:0051536 iron-sulfur cluster binding
Biological Process
GO:0016226 iron-sulfur cluster assembly
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000136003
View Gene Order
ENSMUSG00000025825
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_188937
Metabolism pathway
REACT_199053
Mitochondrial iron-sulfur cluster biogenesis pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL Q17QE6
UniProt Splice Variant
Entrez Gene 533308
UniGene Bt.87803
RefSeq NM_001075683 NM_001243316
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC118409 DAAA02045495
GenPept AAI18410
RNA Seq Atlas 514789 533308

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca