Version 5.4
Mus musculus Gene: Selplg
Summary
InnateDB Gene IDBG-191890.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Selplg
Gene Name selectin, platelet (p-selectin) ligand
Synonyms CD162; Psgl-1; Psgl1; Selp1; Selpl
Species Mus musculus
Ensembl Gene ENSMUSG00000048163
Encoded Proteins
IDBP-191894
selectin, platelet (p-selectin) ligand
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000110876:
This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:113817798-113830501
Strand Reverse strand
Band F
Transcripts
ENSMUST00000100874 ENSMUSP00000098436
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0050901 leukocyte tethering or rolling
GO:0050902 leukocyte adhesive activation
GO:0071354 cellular response to interleukin-6
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000110876
View Gene Order
ENSBTAG00000031851
Not yet available
Pathways
NETPATH
REACTOME
REACT_224553
Hemostasis pathway
REACT_225233
Cell surface interactions at the vascular wall pathway
KEGG
mmu04514
Cell adhesion molecules (CAMs) pathway
mmu05150
Staphylococcus aureus infection pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_12051
Cell surface interactions at the vascular wall pathway
REACT_604
Hemostasis pathway
KEGG
hsa04514
Cell adhesion molecules (CAMs) pathway
hsa05150
Staphylococcus aureus infection pathway
INOH
PID NCI
amb2_neutrophils_pathway
amb2 Integrin signaling
Cross-References
SwissProt Q62170
TrEMBL Q3TA56
UniProt Splice Variant
Entrez Gene 20345
UniGene Mm.332590 Mm.416231
RefSeq NM_009151 XM_006530229
OMIM
CCDS CCDS51621
HPRD
IMGT
MGI ID MGI:106689
MGI Symbol Selplg
EMBL AC159240 AK172077 CH466529 X91144
GenPept BAE42814 CAA62583 EDL19934
RNA Seq Atlas 20345

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca