Version 5.4
Homo sapiens Gene: SELPLG
Summary
InnateDB Gene IDBG-55469.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SELPLG
Gene Name selectin P ligand
Synonyms CD162; CLA; PSGL-1; PSGL1
Species Homo sapiens
Ensembl Gene ENSG00000110876
Encoded Proteins
IDBP-55471
selectin P ligand
IDBP-55473
selectin P ligand
IDBP-599145
selectin P ligand
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:108622277-108633959
Strand Reverse strand
Band q24.11
Transcripts
ENST00000228463 ENSP00000228463
ENST00000388962 ENSP00000373614
ENST00000550948 ENSP00000447752
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 19 [view]
Protein-Protein 19 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005515 protein binding
Biological Process
GO:0007155 cell adhesion
GO:0007596 blood coagulation
GO:0050900 leukocyte migration
GO:0050901 leukocyte tethering or rolling
GO:0050902 leukocyte adhesive activation
GO:0071354 cellular response to interleukin-6
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000048163
View Gene Order
ENSBTAG00000031851
Not yet available
Pathways
NETPATH
REACTOME
REACT_12051
Cell surface interactions at the vascular wall pathway
REACT_604
Hemostasis pathway
KEGG
hsa04514
Cell adhesion molecules (CAMs) pathway
hsa05150
Staphylococcus aureus infection pathway
INOH
PID NCI
amb2_neutrophils_pathway
amb2 Integrin signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.591014
RefSeq NM_001206609 NM_003006
HUGO
OMIM
CCDS CCDS31895 CCDS55881
HPRD 02845
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca