Version 5.4
Mus musculus Gene: Tfdp2
Summary
InnateDB Gene IDBG-191920.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tfdp2
Gene Name transcription factor Dp 2
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000032411
Encoded Proteins
IDBP-191922
transcription factor Dp 2
IDBP-623359
transcription factor Dp 2
IDBP-623362
transcription factor Dp 2
IDBP-742341
IDBP-742176
IDBP-788611
transcription factor Dp 2
IDBP-788612
transcription factor Dp 2
IDBP-788613
transcription factor Dp 2
IDBP-788615
transcription factor Dp 2
IDBP-788616
transcription factor Dp 2
IDBP-788617
transcription factor Dp 2
IDBP-788620
transcription factor Dp 2
IDBP-788622
transcription factor Dp 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000114126:
The gene is a member of the transcription factor DP family. The encoded protein forms heterodimers with the E2F transcription factors resulting in transcriptional activation of cell cycle regulated genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:96196275-96323646
Strand Forward strand
Band E3.3
Transcripts
ENSMUST00000034982 ENSMUSP00000034982
ENSMUST00000165768 ENSMUSP00000128260
ENSMUST00000165120 ENSMUSP00000132934
ENSMUST00000179416 ENSMUSP00000137176
ENSMUST00000179065 ENSMUSP00000136817
ENSMUST00000188008 ENSMUSP00000139848
ENSMUST00000188750 ENSMUSP00000139926
ENSMUST00000185644 ENSMUSP00000140061
ENSMUST00000190709
ENSMUST00000188829 ENSMUSP00000140359
ENSMUST00000186609 ENSMUSP00000139891
ENSMUST00000190104 ENSMUSP00000140797
ENSMUST00000189606 ENSMUSP00000141084
ENSMUST00000191390
ENSMUST00000190689
ENSMUST00000191133 ENSMUSP00000139395
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003712 transcription cofactor activity
GO:0008134 transcription factor binding
GO:0019904 protein domain specific binding
Biological Process
GO:0000278 mitotic cell cycle
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007049 cell cycle
GO:0007507 heart development
Cellular Component
GO:0005635 nuclear envelope
GO:0005667 transcription factor complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000114126
View Gene Order
ENSBTAG00000006222
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04110
Cell cycle pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_7
TGF_beta_Receptor pathway
REACTOME
REACT_111214
G0 and Early G1 pathway
REACT_821
Cyclin D associated events in G1 pathway
REACT_120734
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription pathway
REACT_118568
Pre-NOTCH Transcription and Translation pathway
REACT_12627
Generic Transcription Pathway pathway
REACT_1590
G1 Phase pathway
REACT_169107
SMAD4 MH2 Domain Mutants in Cancer pathway
REACT_169219
Loss of Function of SMAD4 in Cancer pathway
REACT_169398
Loss of Function of SMAD2/3 in Cancer pathway
REACT_118744
Pre-NOTCH Expression and Processing pathway
REACT_169122
Signaling by TGF-beta Receptor Complex in Cancer pathway
REACT_21267
Mitotic G1-G1/S phases pathway
REACT_169192
TGFBR2 MSI Frameshift Mutants in Cancer pathway
REACT_111102
Signal Transduction pathway
REACT_121061
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway
REACT_169165
SMAD2/3 MH2 Domain Mutants in Cancer pathway
REACT_169435
Loss of Function of TGFBR2 in Cancer pathway
REACT_115566
Cell Cycle pathway
REACT_169103
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
REACT_299
Signaling by NOTCH pathway
REACT_169263
TGFBR1 KD Mutants in Cancer pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_169311
Loss of Function of TGFBR1 in Cancer pathway
REACT_169445
TGFBR1 LBD Mutants in Cancer pathway
REACT_169440
TGFBR2 Kinase Domain Mutants in Cancer pathway
REACT_71
Gene Expression pathway
REACT_116125
Disease pathway
REACT_6844
Signaling by TGF-beta Receptor Complex pathway
KEGG
hsa04110
Cell cycle pathway
INOH
PID NCI
e2f_pathway
E2F transcription factor network
Cross-References
SwissProt
TrEMBL Q3TR88
UniProt Splice Variant
Entrez Gene 211586
UniGene
RefSeq NM_001184706 NM_001184708 NM_001184709 NM_001184710 NM_001184711 NM_178667 XM_006510961 XM_006510962 XM_006510963 XM_006510964 XM_006510965 XM_006510966 XM_006510967 XM_006510968 XM_006510969 XM_006510970 XM_006510971 XM_006510972 XM_006510973 XM_006510974 XM_006510975 XM_006510976 XM_006510977 XM_006510978 XM_006510979 XM_006510980 XM_006510981
OMIM
CCDS CCDS23413 CCDS52892 CCDS52893 CCDS57690
HPRD
IMGT
MGI ID MGI:107167
MGI Symbol Tfdp2
EMBL AK162972
GenPept BAE37142
RNA Seq Atlas 211586

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca