Version 5.4
Homo sapiens Gene: TFDP2
Summary
InnateDB Gene IDBG-59316.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TFDP2
Gene Name transcription factor Dp-2 (E2F dimerization partner 2)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000114126
Encoded Proteins
IDBP-484604
transcription factor Dp-2 (E2F dimerization partner 2)
IDBP-483900
transcription factor Dp-2 (E2F dimerization partner 2)
IDBP-473360
transcription factor Dp-2 (E2F dimerization partner 2)
IDBP-483132
transcription factor Dp-2 (E2F dimerization partner 2)
IDBP-476761
transcription factor Dp-2 (E2F dimerization partner 2)
IDBP-484874
transcription factor Dp-2 (E2F dimerization partner 2)
IDBP-476399
transcription factor Dp-2 (E2F dimerization partner 2)
IDBP-473483
transcription factor Dp-2 (E2F dimerization partner 2)
IDBP-479171
transcription factor Dp-2 (E2F dimerization partner 2)
IDBP-482410
transcription factor Dp-2 (E2F dimerization partner 2)
IDBP-475183
transcription factor Dp-2 (E2F dimerization partner 2)
IDBP-481703
transcription factor Dp-2 (E2F dimerization partner 2)
IDBP-813521
transcription factor Dp-2 (E2F dimerization partner 2)
IDBP-474256
transcription factor Dp-2 (E2F dimerization partner 2)
IDBP-478076
transcription factor Dp-2 (E2F dimerization partner 2)
IDBP-485240
transcription factor Dp-2 (E2F dimerization partner 2)
IDBP-583137
transcription factor Dp-2 (E2F dimerization partner 2)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The gene is a member of the transcription factor DP family. The encoded protein forms heterodimers with the E2F transcription factors resulting in transcriptional activation of cell cycle regulated genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:141951147-142149544
Strand Reverse strand
Band q23
Transcripts
ENST00000489671 ENSP00000420616
ENST00000486111 ENSP00000420599
ENST00000477292 ENSP00000418971
ENST00000495310 ENSP00000419036
ENST00000467072 ENSP00000418590
ENST00000479040 ENSP00000417585
ENST00000487734 ENSP00000417384
ENST00000474279 ENSP00000419507
ENST00000467667 ENSP00000417726
ENST00000478006 ENSP00000418122
ENST00000497579 ENSP00000417220
ENST00000492919
ENST00000493204
ENST00000464782
ENST00000488107 ENSP00000420456
ENST00000494656 ENSP00000473436
ENST00000475734 ENSP00000417108
ENST00000471095
ENST00000494358 ENSP00000420657
ENST00000467634 ENSP00000419540
ENST00000495095
ENST00000476617
ENST00000491667
ENST00000499676 ENSP00000439782
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003712 transcription cofactor activity
GO:0008134 transcription factor binding
GO:0019904 protein domain specific binding
Biological Process
GO:0000278 mitotic cell cycle
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0007049 cell cycle
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007219 Notch signaling pathway
GO:0010467 gene expression
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:2001141 regulation of RNA biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032411
View Gene Order
ENSBTAG00000006222
Not yet available
Pathways
NETPATH
NetPath_7
TGF_beta_Receptor pathway
REACTOME
REACT_111214
G0 and Early G1 pathway
REACT_821
Cyclin D associated events in G1 pathway
REACT_120734
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription pathway
REACT_118568
Pre-NOTCH Transcription and Translation pathway
REACT_12627
Generic Transcription Pathway pathway
REACT_1590
G1 Phase pathway
REACT_169107
SMAD4 MH2 Domain Mutants in Cancer pathway
REACT_169219
Loss of Function of SMAD4 in Cancer pathway
REACT_169398
Loss of Function of SMAD2/3 in Cancer pathway
REACT_118744
Pre-NOTCH Expression and Processing pathway
REACT_169122
Signaling by TGF-beta Receptor Complex in Cancer pathway
REACT_21267
Mitotic G1-G1/S phases pathway
REACT_169192
TGFBR2 MSI Frameshift Mutants in Cancer pathway
REACT_111102
Signal Transduction pathway
REACT_121061
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway
REACT_169165
SMAD2/3 MH2 Domain Mutants in Cancer pathway
REACT_169435
Loss of Function of TGFBR2 in Cancer pathway
REACT_115566
Cell Cycle pathway
REACT_169103
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
REACT_299
Signaling by NOTCH pathway
REACT_169263
TGFBR1 KD Mutants in Cancer pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_169311
Loss of Function of TGFBR1 in Cancer pathway
REACT_169445
TGFBR1 LBD Mutants in Cancer pathway
REACT_169440
TGFBR2 Kinase Domain Mutants in Cancer pathway
REACT_71
Gene Expression pathway
REACT_116125
Disease pathway
REACT_6844
Signaling by TGF-beta Receptor Complex pathway
KEGG
hsa04110
Cell cycle pathway
INOH
PID NCI
e2f_pathway
E2F transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.379018 Hs.679726
RefSeq NM_001178138 NM_001178139 NM_001178141 NM_001178142 NM_006286 XM_005247735 NM_001178140 XM_005247734 XM_006713737
HUGO
OMIM
CCDS CCDS43159 CCDS54647 CCDS54649 CCDS54650 CCDS54648
HPRD 03696
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca