Version 5.4
Mus musculus Gene: Rap1b
Summary
InnateDB Gene IDBG-191995.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rap1b
Gene Name RAS related protein 1b
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000052681
Encoded Proteins
IDBP-191997
RAS related protein 1b
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000127314:
This gene encodes a member of the RAS-like small GTP-binding protein superfamily. Members of this family regulate multiple cellular processes including cell adhesion and growth and differentiation. This protein localizes to cellular membranes and has been shown to regulate integrin-mediated cell signaling. This protein also plays a role in regulating outside-in signaling in platelets. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 3, 5, 6 and 9. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:117814471-117845935
Strand Reverse strand
Band D2
Transcripts
ENSMUST00000064667 ENSMUSP00000066238
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 33 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0019003 GDP binding
GO:0032403 protein complex binding
Biological Process
GO:0006184 GTP catabolic process
GO:0006886 intracellular protein transport
GO:0006913 nucleocytoplasmic transport
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0008283 cell proliferation
GO:0015031 protein transport
GO:0032486 Rap protein signal transduction
GO:0045955 negative regulation of calcium ion-dependent exocytosis
GO:0061028 establishment of endothelial barrier
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071320 cellular response to cAMP
GO:1901888 regulation of cell junction assembly
GO:2000114 regulation of establishment of cell polarity
GO:2000301 negative regulation of synaptic vesicle exocytosis
Cellular Component
GO:0005622 intracellular
GO:0005811 lipid particle
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000127314
View Gene Order
ENSBTAG00000008967
Not yet available
Pathways
NETPATH
REACTOME
REACT_224553
Hemostasis pathway
REACT_230745
Immune System pathway
REACT_224879
Platelet activation, signaling and aggregation pathway
REACT_237855
Rap1 signalling pathway
REACT_238268
GRB2:SOS provides linkage to MAPK signaling for Integrins pathway
REACT_229531
Adaptive Immune System pathway
REACT_240371
p130Cas linkage to MAPK signaling for integrins pathway
REACT_188257
Signal Transduction pathway
REACT_246176
Integrin alphaIIb beta3 signaling pathway
REACT_249309
Platelet Aggregation (Plug Formation) pathway
KEGG
mmu05211
Renal cell carcinoma pathway
mmu04010
MAPK signaling pathway pathway
mmu04720
Long-term potentiation pathway
mmu04670
Leukocyte transendothelial migration pathway
mmu04510
Focal adhesion pathway
mmu04062
Chemokine signaling pathway pathway
mmu04722
Neurotrophin signaling pathway pathway
mmu04972
Pancreatic secretion pathway
INOH
INOH website
Integrin signaling pathway pathway
INOH website
GPCR Adenosine A2A receptor signaling pathway pathway
INOH website
HGF signaling pathway pathway
INOH website
GPCR signaling pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_23898
Rap1 signalling pathway
REACT_15443
GRB2:SOS provides linkage to MAPK signaling for Integrins pathway
REACT_15381
p130Cas linkage to MAPK signaling for integrins pathway
REACT_15523
Integrin alphaIIb beta3 signaling pathway
REACT_278
Platelet Aggregation (Plug Formation) pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_111102
Signal Transduction pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_604
Hemostasis pathway
REACT_212196
Hemostasis pathway
REACT_213138
Immune System pathway
REACT_209572
Platelet activation, signaling and aggregation pathway
REACT_217199
Platelet Aggregation (Plug Formation) pathway
REACT_214353
Signal Transduction pathway
REACT_221144
p130Cas linkage to MAPK signaling for integrins pathway
REACT_223002
GRB2:SOS provides linkage to MAPK signaling for Integrins pathway
REACT_206808
Integrin alphaIIb beta3 signaling pathway
REACT_214469
Adaptive Immune System pathway
REACT_214141
Rap1 signalling pathway
KEGG
hsa05211
Renal cell carcinoma pathway
hsa04010
MAPK signaling pathway pathway
hsa04720
Long-term potentiation pathway
hsa04670
Leukocyte transendothelial migration pathway
hsa04510
Focal adhesion pathway
hsa04722
Neurotrophin signaling pathway pathway
hsa04062
Chemokine signaling pathway pathway
hsa04972
Pancreatic secretion pathway
INOH
INOH website
Integrin signaling pathway pathway
INOH website
GPCR Adenosine A2A receptor signaling pathway pathway
INOH website
HGF signaling pathway pathway
INOH website
GPCR signaling pathway
PID NCI
cxcr4_pathway
CXCR4-mediated signaling events
Cross-References
SwissProt Q99JI6
TrEMBL Q52L50
UniProt Splice Variant
Entrez Gene 215449
UniGene Mm.233009 Mm.392484
RefSeq NM_024457
OMIM
CCDS CCDS24196
HPRD
IMGT
MGI ID MGI:894315
MGI Symbol Rap1b
EMBL AK143910 AK153870 AK163242 AK167548 BC033382 BC052480 BC094066 BC147390 BC147391 BC147700 BC147713 CH466539 M79314
GenPept AAH33382 AAH52480 AAH94066 AAI47391 AAI47392 AAI47701 AAI47714 AAK14823 BAE25597 BAE32223 BAE37252 BAE39614 EDL21849 EDL21850
RNA Seq Atlas 215449

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca