Version 5.4
Homo sapiens Gene: RAP1B
Summary
InnateDB Gene IDBG-46140.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RAP1B
Gene Name RAP1B, member of RAS oncogene family
Synonyms K-REV; RAL1B
Species Homo sapiens
Ensembl Gene ENSG00000127314
Encoded Proteins
IDBP-36998
RAP1B, member of RAS oncogene family
IDBP-46142
RAP1B, member of RAS oncogene family
IDBP-599093
RAP1B, member of RAS oncogene family
IDBP-243414
RAP1B, member of RAS oncogene family
IDBP-363954
RAP1B, member of RAS oncogene family
IDBP-588288
RAP1B, member of RAS oncogene family
IDBP-379684
RAP1B, member of RAS oncogene family
IDBP-379685
RAP1B, member of RAS oncogene family
IDBP-585548
RAP1B, member of RAS oncogene family
IDBP-602752
RAP1B, member of RAS oncogene family
IDBP-595504
RAP1B, member of RAS oncogene family
IDBP-603715
RAP1B, member of RAS oncogene family
IDBP-598119
RAP1B, member of RAS oncogene family
IDBP-590417
RAP1B, member of RAS oncogene family
IDBP-597644
RAP1B, member of RAS oncogene family
IDBP-591860
RAP1B, member of RAS oncogene family
IDBP-592490
RAP1B, member of RAS oncogene family
IDBP-589354
RAP1B, member of RAS oncogene family
IDBP-585422
RAP1B, member of RAS oncogene family
IDBP-593651
RAP1B, member of RAS oncogene family
IDBP-592755
RAP1B, member of RAS oncogene family
IDBP-589100
RAP1B, member of RAS oncogene family
IDBP-603713
RAP1B, member of RAS oncogene family
IDBP-589543
RAP1B, member of RAS oncogene family
IDBP-602151
RAP1B, member of RAS oncogene family
IDBP-591506
RAP1B, member of RAS oncogene family
IDBP-594079
RAP1B, member of RAS oncogene family
IDBP-591313
RAP1B, member of RAS oncogene family
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the RAS-like small GTP-binding protein superfamily. Members of this family regulate multiple cellular processes including cell adhesion and growth and differentiation. This protein localizes to cellular membranes and has been shown to regulate integrin-mediated cell signaling. This protein also plays a role in regulating outside-in signaling in platelets. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 3, 5, 6 and 9. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:68610839-68671901
Strand Forward strand
Band q15
Transcripts
ENST00000378985 ENSP00000368270
ENST00000250559 ENSP00000250559
ENST00000341355 ENSP00000441275
ENST00000393436 ENSP00000377085
ENST00000422358 ENSP00000390972
ENST00000453560 ENSP00000444060
ENST00000450214 ENSP00000399986
ENST00000425247 ENSP00000401095
ENST00000501412
ENST00000460800
ENST00000485252 ENSP00000444924
ENST00000463493
ENST00000489473 ENSP00000446027
ENST00000541167 ENSP00000445138
ENST00000538283 ENSP00000444786
ENST00000537460 ENSP00000439966
ENST00000545270 ENSP00000437415
ENST00000538980 ENSP00000444467
ENST00000542018 ENSP00000438088
ENST00000543393 ENSP00000445090
ENST00000534899 ENSP00000441952
ENST00000540209 ENSP00000446318
ENST00000540781 ENSP00000440466
ENST00000535492 ENSP00000443775
ENST00000539091 ENSP00000444830
ENST00000542145 ENSP00000440014
ENST00000541386 ENSP00000445977
ENST00000538877 ENSP00000440635
ENST00000543697 ENSP00000440708
ENST00000545720 ENSP00000438311
ENST00000541216 ENSP00000443851
ENST00000544639
ENST00000541968
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 60 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 60 [view]
Protein-Protein 60 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0019003 GDP binding
GO:0032403 protein complex binding
Biological Process
GO:0006112 energy reserve metabolic process
GO:0006184 GTP catabolic process
GO:0006886 intracellular protein transport
GO:0006913 nucleocytoplasmic transport
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0007596 blood coagulation
GO:0008283 cell proliferation
GO:0015031 protein transport
GO:0030168 platelet activation
GO:0032486 Rap protein signal transduction
GO:0044281 small molecule metabolic process
GO:0045955 negative regulation of calcium ion-dependent exocytosis
GO:0050796 regulation of insulin secretion
GO:0061028 establishment of endothelial barrier
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071320 cellular response to cAMP
GO:1901888 regulation of cell junction assembly
GO:2000114 regulation of establishment of cell polarity
GO:2000301 negative regulation of synaptic vesicle exocytosis
Cellular Component
GO:0005622 intracellular
GO:0005811 lipid particle
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000052681
View Gene Order
ENSBTAG00000008967
Not yet available
Pathways
NETPATH
REACTOME
REACT_23898
Rap1 signalling pathway
REACT_15443
GRB2:SOS provides linkage to MAPK signaling for Integrins pathway
REACT_15381
p130Cas linkage to MAPK signaling for integrins pathway
REACT_15523
Integrin alphaIIb beta3 signaling pathway
REACT_278
Platelet Aggregation (Plug Formation) pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_111102
Signal Transduction pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_604
Hemostasis pathway
KEGG
hsa05211
Renal cell carcinoma pathway
hsa04010
MAPK signaling pathway pathway
hsa04720
Long-term potentiation pathway
hsa04670
Leukocyte transendothelial migration pathway
hsa04510
Focal adhesion pathway
hsa04722
Neurotrophin signaling pathway pathway
hsa04062
Chemokine signaling pathway pathway
hsa04972
Pancreatic secretion pathway
INOH
INOH website
Integrin signaling pathway pathway
INOH website
GPCR Adenosine A2A receptor signaling pathway pathway
INOH website
HGF signaling pathway pathway
INOH website
GPCR signaling pathway
PID NCI
cxcr4_pathway
CXCR4-mediated signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.369920 Hs.694169
RefSeq NM_001010942 NM_001251917 NM_001251918 NM_001251921 NM_001251922 NM_015646
HUGO
OMIM
CCDS CCDS58252 CCDS58253 CCDS58254 CCDS8984
HPRD 01546
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca