Version 5.4
Mus musculus Gene: Helb
Summary
InnateDB Gene IDBG-192467.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Helb
Gene Name helicase (DNA) B
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000020228
Encoded Proteins
IDBP-192469
helicase (DNA) B
IDBP-537878
helicase (DNA) B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000127311:
This gene encodes a DNA-dependent ATPase which catalyzes the unwinding of DNA necessary for DNA replication, repair, recombination, and transcription. This gene is thought to function specifically during the S phase entry of the cell cycle. [provided by RefSeq, Mar 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:120083608-120112987
Strand Reverse strand
Band D2
Transcripts
ENSMUST00000020449 ENSMUSP00000020449
ENSMUST00000148241
ENSMUST00000154501 ENSMUSP00000116954
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003707 steroid hormone receptor activity
GO:0004003 ATP-dependent DNA helicase activity
GO:0005524 ATP binding
GO:0017116 single-stranded DNA-dependent ATP-dependent DNA helicase activity
GO:0043141 ATP-dependent 5'-3' DNA helicase activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-dependent DNA replication
GO:0006269 DNA replication, synthesis of RNA primer
GO:0032508 DNA duplex unwinding
Cellular Component
GO:0005634 nucleus
GO:0005658 alpha DNA polymerase:primase complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000127311
View Gene Order
ENSBTAG00000020806
Not yet available
Cross-References
SwissProt Q6NVF4
TrEMBL D6RGT6
UniProt Splice Variant
Entrez Gene 117599
UniGene Mm.214703
RefSeq NM_080446
OMIM
CCDS CCDS24203
HPRD
IMGT
MGI ID MGI:2152895
MGI Symbol Helb
EMBL AB048542 AC134326 AC144942 AK043127 AK131122 BC068140 CH466578
GenPept AAH68140 BAB20809 BAC31468 BAD21372 EDL24397
RNA Seq Atlas 117599

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca