Version 5.4
Mus musculus Gene: Ppp1r15b
Summary
InnateDB Gene IDBG-192577.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ppp1r15b
Gene Name protein phosphatase 1, regulatory (inhibitor) subunit 15b
Synonyms 1810033K10Rik; AI606441; C530022L24Rik; CReP
Species Mus musculus
Ensembl Gene ENSMUSG00000046062
Encoded Proteins
IDBP-192579
protein phosphatase 1, regulatory (inhibitor) subunit 15b
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000158615:
PPP1R15B promotes dephosphorylation of the transcription initiation factor EIF2-alpha (EIF2S1; MIM 603907) through recruitment of protein phosphatase-1 (PP1) catalytic subunits (see MIM 176875) (Harding et al., 2009 [PubMed 19181853]).[supplied by OMIM, Feb 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:133131143-133139783
Strand Forward strand
Band E4
Transcripts
ENSMUST00000052529 ENSMUSP00000057062
ENSMUST00000122956
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004722 protein serine/threonine phosphatase activity
GO:0005515 protein binding
GO:0045182 translation regulator activity
Biological Process
GO:0006446 regulation of translational initiation
GO:0006979 response to oxidative stress
GO:0006983 ER overload response
GO:0016311 dephosphorylation
GO:0034976 response to endoplasmic reticulum stress
GO:0042542 response to hydrogen peroxide
Cellular Component
GO:0000164 protein phosphatase type 1 complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000158615
View Gene Order
ENSBTAG00000013074
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.293628 Mm.414175 Mm.427930
RefSeq NM_133819
OMIM
CCDS CCDS15291
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca