InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ppp1r15b

Summary

InnateDB Protein

IDBP-192579.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ppp1r15b

Protein Name

protein phosphatase 1, regulatory (inhibitor) subunit 15b

Synonyms

1810033K10Rik; AI606441; C530022L24Rik; CReP;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000057062

InnateDB Gene

IDBG-192577 (Ppp1r15b)

Protein Structure

UniProt Annotation

Function

Maintains low levels of EIF2S1 phosphorylation in unstressed cells by promoting its dephosphorylation by PP1. {ECO:0000269PubMed:14638860, ECO:0000269PubMed:19181853}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004722	protein serine/threonine phosphatase activity
GO:0005515	protein binding
GO:0045182	translation regulator activity

Biological Process

GO:0006446	regulation of translational initiation
GO:0006979	response to oxidative stress
GO:0006983	ER overload response
GO:0016311	dephosphorylation
GO:0034976	response to endoplasmic reticulum stress
GO:0042542	response to hydrogen peroxide