Version 5.4
Mus musculus Gene: Gps2
Summary
InnateDB Gene IDBG-192712.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gps2
Gene Name G protein pathway suppressor 2
Synonyms AI505953
Species Mus musculus
Ensembl Gene ENSMUSG00000023170
Encoded Proteins
IDBP-192714
G protein pathway suppressor 2
IDBP-192716
G protein pathway suppressor 2
IDBP-274315
G protein pathway suppressor 2
IDBP-718338
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000132522:
This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:69913888-69916591
Strand Forward strand
Band B3
Transcripts
ENSMUST00000072581 ENSMUSP00000072389
ENSMUST00000057884 ENSMUSP00000054072
ENSMUST00000116358 ENSMUSP00000112062
ENSMUST00000124596
ENSMUST00000134581 ENSMUSP00000136921
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0046329 negative regulation of JNK cascade
Cellular Component
GO:0005634 nucleus
GO:0017053 transcriptional repressor complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000132522
View Gene Order
ENSBTAG00000010513
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_228222
HDACs deacetylate histones pathway
REACT_172623
Chromatin organization pathway
REACT_172633
Chromatin modifying enzymes pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.477738
RefSeq NM_019726 XM_006533785 XM_006533786 XM_006533787 XM_006537188 XM_006537189 XM_006537190
OMIM
CCDS CCDS24922
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca