Homo sapiens Gene: GPS2

Summary
InnateDB Gene IDBG-24467.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol GPS2
Gene Name G protein pathway suppressor 2
Synonyms AMF-1
Species Homo sapiens
Ensembl Gene ENSG00000132522
Encoded Proteins
IDBP-24469 G protein pathway suppressor 2
IDBP-237149 G protein pathway suppressor 2
IDBP-589350 G protein pathway suppressor 2
IDBP-763700
IDBP-759787
IDBP-758613
IDBP-763628
Entrez Gene
Summary This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17: 7214643-7218883
Strand Reverse strand
Band p13.1
Transcripts
ENST00000380728  ENSP00000370104
ENST00000389167  ENSP00000379841
ENST00000391950  ENSP00000438697
ENST00000571697 
ENST00000571569 
ENST00000574201 
ENST00000570780  ENSP00000460836
ENST00000572707 
ENST00000571695 
ENST00000573684  ENSP00000458837
ENST00000574458  ENSP00000459357
ENST00000572172 
ENST00000571098 
ENST00000573059 
ENST00000577040  ENSP00000461624
ENST00000572363 
ENST00000573807 
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein‑Protein  17
[view]
Protein‑DNA 0
Protein‑RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
 
Predicted by orthology
Total [view]
Gene Ontology
Accession GO Term
Molecular Function
GO:0003714 transcription corepressor activity
GO:0005095 GTPase inhibitor activity
GO:0005515 protein binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000188 inactivation of MAPK activity
GO:0007049 cell cycle
GO:0007254 JNK cascade
GO:0046329 negative regulation of JNK cascade
Cellular Component
GO:0005634 nucleus
GO:0017053 transcriptional repressor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID Gene Order Method Confidence Comments
ENSMUSG00000023170 Ortholuge Non-SSD Ortholog Possible paralog/unusual divergence/ gene prediction error
ENSBTAG00000010513 Not yet available Ortholuge Non-SSD Ortholog Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q13227 
TrEMBL B4DXA1 I3L1H4 I3L4X7
UniProt Splice Variant
Entrez Gene 2874 
UniGene Hs.438219
RefSeq
HUGO 4550 
OMIM 601935
CCDS CCDS11100 
HPRD 11878
IMGT
EMBL AC026954 AK301877 AL122080 AL157493 BC013652 BC103901 BC103903 BC107738 BT006998 CR541723 CR541750 U28963
GenPept AAB60432  AAH13652  AAI03902  AAI03904  AAI07739  AAP35644  BAG63313  CAB59255  CAB75677  CAG46524  CAG46550 
ImmGen GPS2 (murine) 
RNA Seq Atlas 2874