Homo sapiens Gene: GPS2
Summary
InnateDB Gene IDBG-24467.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GPS2
Gene Name G protein pathway suppressor 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000132522
Encoded Proteins
G protein pathway suppressor 2
G protein pathway suppressor 2
Protein Structure
Entrez Gene
Summary This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:7311324-7315564
Strand Reverse strand
Band p13.1
Transcripts
ENST00000380728 ENSP00000370104
ENST00000389167 ENSP00000379841
ENST00000571697
ENST00000571569
ENST00000574201
ENST00000570780 ENSP00000460836
ENST00000572707
ENST00000571695
ENST00000573684 ENSP00000458837
ENST00000574458 ENSP00000459357
ENST00000572172
ENST00000571098
ENST00000573059
ENST00000577040 ENSP00000461624
ENST00000572363
ENST00000573807
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 55 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 55 [view]
Protein-Protein 53 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003714 transcription corepressor activity
GO:0005095 GTPase inhibitor activity
GO:0005515 protein binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000188 inactivation of MAPK activity
GO:0007049 cell cycle
GO:0007254 JNK cascade
GO:0046329 negative regulation of JNK cascade
Cellular Component
GO:0005634 nucleus
GO:0017053 transcriptional repressor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
HDACs deacetylate histones pathway
Chromatin organization pathway
Chromatin modifying enzymes pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q13227
TrEMBL B4DXA1 I3L1H4 I3L4X7
UniProt Splice Variant
Entrez Gene 2874
UniGene Hs.438219
RefSeq NM_004489
HUGO HGNC:4550
OMIM 601935
CCDS CCDS11100
HPRD 11878
IMGT
EMBL AC026954 AK301877 AL122080 AL157493 BC013652 BC103901 BC103903 BC107738 BT006998 CR541723 CR541750 U28963
GenPept AAB60432 AAH13652 AAI03902 AAI03904 AAI07739 AAP35644 BAG63313 CAB59255 CAB75677 CAG46524 CAG46550
ImmGen GPS2 (murine)
RNA Seq Atlas 2874