Version 5.4
Homo sapiens Gene: GPS2
Summary
InnateDB Gene IDBG-24467.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GPS2
Gene Name G protein pathway suppressor 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000132522
Encoded Proteins
IDBP-24469
G protein pathway suppressor 2
IDBP-237149
G protein pathway suppressor 2
IDBP-763700
IDBP-759787
IDBP-758613
IDBP-763628
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:7311324-7315564
Strand Reverse strand
Band p13.1
Transcripts
ENST00000380728 ENSP00000370104
ENST00000389167 ENSP00000379841
ENST00000571697
ENST00000571569
ENST00000574201
ENST00000570780 ENSP00000460836
ENST00000572707
ENST00000571695
ENST00000573684 ENSP00000458837
ENST00000574458 ENSP00000459357
ENST00000572172
ENST00000571098
ENST00000573059
ENST00000577040 ENSP00000461624
ENST00000572363
ENST00000573807
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 56 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 56 [view]
Protein-Protein 54 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003714 transcription corepressor activity
GO:0005095 GTPase inhibitor activity
GO:0005515 protein binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000188 inactivation of MAPK activity
GO:0007049 cell cycle
GO:0007254 JNK cascade
GO:0046329 negative regulation of JNK cascade
Cellular Component
GO:0005634 nucleus
GO:0017053 transcriptional repressor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000023170
View Gene Order
ENSBTAG00000010513
Not yet available
Pathways
NETPATH
REACTOME
REACT_228222
HDACs deacetylate histones pathway
REACT_172623
Chromatin organization pathway
REACT_172633
Chromatin modifying enzymes pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL I3L1H4
UniProt Splice Variant
Entrez Gene 2874
UniGene Hs.438219
RefSeq NM_004489
HUGO HGNC:4550
OMIM 601935
CCDS CCDS11100
HPRD 11878
IMGT
EMBL AC026954
GenPept
RNA Seq Atlas 2874

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca