Homo sapiens Gene: DPP9
Summary
InnateDB Gene IDBG-19280.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DPP9
Gene Name dipeptidyl-peptidase 9
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000142002
Encoded Proteins
dipeptidyl-peptidase 9
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that is a member of the S9B family in clan SC of the serine proteases. The protein has been shown to have post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Although the activity of this protein is similar to that of dipeptidyl peptidase 4 (DPP4), it does not appear to be membrane bound. In general, dipeptidyl peptidases appear to be involved in the regulation of the activity of their substrates and have been linked to a variety of diseases including type 2 diabetes, obesity and cancer. Several transcript variants of this gene have been described but not fully characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:4675224-4724673
Strand Reverse strand
Band p13.3
Transcripts
ENST00000262960 ENSP00000262960
ENST00000597726 ENSP00000473175
ENST00000593973 ENSP00000469282
ENST00000601173
ENST00000597024
ENST00000595940
ENST00000594671 ENSP00000472224
ENST00000599163 ENSP00000471659
ENST00000598360 ENSP00000471250
ENST00000600497
ENST00000601720 ENSP00000469187
ENST00000597253
ENST00000600556 ENSP00000470393
ENST00000599248 ENSP00000469020
ENST00000595327 ENSP00000471954
ENST00000597900 ENSP00000472968
ENST00000601764
ENST00000599998
ENST00000598800 ENSP00000469603
ENST00000598041 ENSP00000469152
ENST00000602161 ENSP00000473130
ENST00000597145
ENST00000597849 ENSP00000472430
ENST00000600621 ENSP00000472549
ENST00000601130 ENSP00000471629
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
Experimentally validated
Total 21 [view]
Protein-Protein 21 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004177 aminopeptidase activity
GO:0008236 serine-type peptidase activity
GO:0016787 hydrolase activity
GO:0042802 identical protein binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.515081
RefSeq NM_139159 XM_005259673 XM_005259674
HUGO
OMIM
CCDS CCDS45928
HPRD 07001
IMGT
EMBL
GenPept
RNA Seq Atlas