InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SRD5A3

Summary

InnateDB Gene

IDBG-19300.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SRD5A3

Gene Name

steroid 5 alpha-reductase 3

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000128039

Encoded Proteins

IDBP-19304

steroid 5 alpha-reductase 3

IDBP-479560

steroid 5 alpha-reductase 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene belongs to the steroid 5-alpha reductase family, and polyprenol reductase subfamily. It is involved in the production of androgen 5-alpha-dihydrotestosterone (DHT) from testosterone, and maintenance of the androgen-androgen receptor activation pathway. This protein is also necessary for the conversion of polyprenol into dolichol, which is required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-linked glycosylation of proteins. Mutations in this gene are associated with congenital disorder of glycosylation type Iq. [provided by RefSeq, Mar 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:55346109-55373096

Strand

Forward strand

Band

q12

Transcripts

ENST00000264228	ENSP00000264228
ENST00000505210	ENSP00000424714
ENST00000514398

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003865	3-oxo-5-alpha-steroid 4-dehydrogenase activity
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
GO:0047751	cholestenone 5-alpha-reductase activity

Biological Process

GO:0006488	dolichol-linked oligosaccharide biosynthetic process
GO:0006489	dolichyl diphosphate biosynthetic process
GO:0006629	lipid metabolic process
GO:0006702	androgen biosynthetic process
GO:0008202	steroid metabolic process
GO:0016095	polyprenol catabolic process
GO:0018279	protein N-linked glycosylation via asparagine
GO:0019348	dolichol metabolic process
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process