Version 5.4
Bos taurus Gene: SRD5A3
Summary
InnateDB Gene IDBG-642364.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SRD5A3
Gene Name probable polyprenol reductase
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000014913
Encoded Proteins
IDBP-694821
steroid 5 alpha-reductase 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000128039:
The protein encoded by this gene belongs to the steroid 5-alpha reductase family, and polyprenol reductase subfamily. It is involved in the production of androgen 5-alpha-dihydrotestosterone (DHT) from testosterone, and maintenance of the androgen-androgen receptor activation pathway. This protein is also necessary for the conversion of polyprenol into dolichol, which is required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-linked glycosylation of proteins. Mutations in this gene are associated with congenital disorder of glycosylation type Iq. [provided by RefSeq, Mar 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:72468365-72518226
Strand Forward strand
Band
Transcripts
ENSBTAT00000019855 ENSBTAP00000019855
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003865 3-oxo-5-alpha-steroid 4-dehydrogenase activity
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors
GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
Biological Process
GO:0006488 dolichol-linked oligosaccharide biosynthetic process
GO:0006629 lipid metabolic process
GO:0016095 polyprenol catabolic process
GO:0019348 dolichol metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000128039
View Gene Order
ENSMUSG00000029233
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_22230
Synthesis of Dolichyl-phosphate pathway
REACT_22433
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein pathway
REACT_22426
Asparagine N-linked glycosylation pathway
REACT_11059
Androgen biosynthesis pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_22161
Post-translational protein modification pathway
REACT_11057
Metabolism of steroid hormones and vitamin D pathway
REACT_22387
Synthesis of substrates in N-glycan biosythesis pathway
REACT_17015
Metabolism of proteins pathway
REACT_111217
Metabolism pathway
REACT_248642
Synthesis of substrates in N-glycan biosythesis pathway
REACT_202113
Synthesis of Dolichyl-phosphate pathway
REACT_262413
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein pathway
REACT_188937
Metabolism pathway
REACT_247926
Metabolism of proteins pathway
REACT_236283
Post-translational protein modification pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_220332
Androgen biosynthesis pathway
REACT_237472
Asparagine N-linked glycosylation pathway
REACT_220061
Metabolism of steroid hormones and vitamin D pathway
KEGG
hsa00140
Steroid hormone biosynthesis pathway
mmu00140
Steroid hormone biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E1BCQ0
UniProt Splice Variant
Entrez Gene 535834
UniGene
RefSeq
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02017729 DAAA02017730 DAAA02017731
GenPept
RNA Seq Atlas 535834

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca