InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Akap13

Summary

InnateDB Gene

IDBG-193054.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Akap13

Gene Name

A kinase (PRKA) anchor protein 13

Synonyms

1700026G02Rik; 5730522G15Rik; 5830460E08Rik; AKAP-Lbc; BRX; Ht31; LBC; PROTO-LB; PROTO-LBC

Species

Mus musculus

Ensembl Gene

ENSMUSG00000066406

Encoded Proteins

IDBP-193068

A kinase (PRKA) anchor protein 13

IDBP-537856

A kinase (PRKA) anchor protein 13

IDBP-535819

A kinase (PRKA) anchor protein 13

IDBP-540234

A kinase (PRKA) anchor protein 13

IDBP-542254

A kinase (PRKA) anchor protein 13

IDBP-627102

A kinase (PRKA) anchor protein 13

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000170776:
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms containing c-terminal dbl oncogene homology (DH) and pleckstrin homology (PH) domains. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP binding proteins, resulting in the conversion of the inactive GTPase to the active form capable of transducing signals. The PH domain has multiple functions. Therefore, these isoforms function as scaffolding proteins to coordinate a Rho signaling pathway, function as protein kinase A-anchoring proteins and, in addition, enhance ligand-dependent activity of estrogen receptors alpha and beta. [provided by RefSeq, Jul 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:75455534-75754609

Strand

Forward strand

Band

Transcripts

ENSMUST00000094307	ENSMUSP00000091865
ENSMUST00000147005	ENSMUSP00000117686
ENSMUST00000136989
ENSMUST00000141666
ENSMUST00000125771	ENSMUSP00000118138
ENSMUST00000154740	ENSMUSP00000121355
ENSMUST00000151560
ENSMUST00000141486
ENSMUST00000141288
ENSMUST00000137959	ENSMUSP00000116573
ENSMUST00000134001
ENSMUST00000132656
ENSMUST00000166315	ENSMUSP00000129784

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	24 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004691	cAMP-dependent protein kinase activity
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0017048	Rho GTPase binding
GO:0032947	protein complex scaffold
GO:0046872	metal ion binding
GO:0051018	protein kinase A binding

Biological Process

GO:0006468	protein phosphorylation
GO:0010611	regulation of cardiac muscle hypertrophy
GO:0032319	regulation of Rho GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0035556	intracellular signal transduction
GO:0045859	regulation of protein kinase activity
GO:0051168	nuclear export
GO:1900169	regulation of glucocorticoid mediated signaling pathway