InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Atp2b4

Summary

InnateDB Gene

IDBG-193105.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Atp2b4

Gene Name

ATPase, Ca++ transporting, plasma membrane 4

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026463

Encoded Proteins

IDBP-193107

ATPase, Ca++ transporting, plasma membrane 4

IDBP-256367

ATPase, Ca++ transporting, plasma membrane 4

IDBP-539350

ATPase, Ca++ transporting, plasma membrane 4

IDBP-539614

ATPase, Ca++ transporting, plasma membrane 4

IDBP-627304

ATPase, Ca++ transporting, plasma membrane 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000058668:
The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 4. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:133699457-133801041

Strand

Reverse strand

Band

Transcripts

ENSMUST00000048953	ENSMUSP00000047978
ENSMUST00000112264	ENSMUSP00000107883
ENSMUST00000143567	ENSMUSP00000119242
ENSMUST00000125659	ENSMUSP00000116941
ENSMUST00000140810
ENSMUST00000128692
ENSMUST00000165602	ENSMUSP00000133187

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005388	calcium-transporting ATPase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0017080	sodium channel regulator activity
GO:0019829	cation-transporting ATPase activity
GO:0046872	metal ion binding
GO:0097110	scaffold protein binding

Biological Process

GO:0006812	cation transport
GO:0006816	calcium ion transport
GO:0008152	metabolic process
GO:0070588	calcium ion transmembrane transport
GO:1902083	negative regulation of peptidyl-cysteine S-nitrosylation
GO:1902305	regulation of sodium ion transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043234	protein complex