InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ATP2B4

Summary

InnateDB Gene

IDBG-628584.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATP2B4

Gene Name

plasma membrane calcium-transporting ATPase 4

Synonyms

PMCA4

Species

Bos taurus

Ensembl Gene

ENSBTAG00000014059

Encoded Proteins

IDBP-679955

ATPase, Ca++ transporting, plasma membrane 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000058668:
The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 4. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:1272937-1313257

Strand

Forward strand

Band

Transcripts

ENSBTAT00000018688

ENSBTAP00000018688

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005388	calcium-transporting ATPase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016787	hydrolase activity
GO:0019829	cation-transporting ATPase activity
GO:0046872	metal ion binding