Mus musculus Gene: Rag2

Summary
InnateDB Gene IDBG-193167.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol Rag2
Gene Name recombination activating gene 2
Synonyms Rag-2
Species Mus musculus
Ensembl Gene ENSMUSG00000032864
Encoded Proteins
IDBP-193169 recombination activating gene 2
IDBP-258576 recombination activating gene 2
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000175097:
This gene encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2: 101624718-101632529
Strand Forward strand
Band E2
Transcripts
ENSMUST00000044031  ENSMUSP00000038204
ENSMUST00000111227  ENSMUSP00000106858
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein‑Protein  2
[view]
Protein‑DNA 7
[view]
Protein‑RNA 0
DNA-DNA 1
[view]
RNA-RNA 0
DNA-RNA 0
 
Predicted by orthology
Total [view]
Gene Ontology
Accession GO Term
Molecular Function
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding
GO:0008270 zinc ion binding
GO:0035064 methylated histone residue binding
GO:0035091 phosphatidylinositol binding
GO:0043325 phosphatidylinositol-3,4-bisphosphate binding
GO:0080025 phosphatidylinositol-3,5-bisphosphate binding
Biological Process
GO:0002326 B cell lineage commitment
GO:0002331 pre-B cell allelic exclusion
GO:0002358 B cell homeostatic proliferation
GO:0002360 T cell lineage commitment
GO:0006310 DNA recombination
GO:0016568 chromatin modification
GO:0030183 B cell differentiation
GO:0030217 T cell differentiation
GO:0033077 T cell differentiation in thymus
GO:0033151 V(D)J recombination
GO:0046622 positive regulation of organ growth
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID Gene Order Method Confidence Comments
ENSG00000175097 Ortholuge SSD Ortholog Ortholog supports species divergence
ENSBTAG00000031309 Not yet available Ortholuge SSD Ortholog Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
mmu05340  Primary immunodeficiency
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa05340  Primary immunodeficiency
INOH
PID BIOCARTA
PID NCI
cmyb_pathway C-MYB transcription factor network
Cross-References
SwissProt P21784 
TrEMBL Q542D1 Q99NM2
UniProt Splice Variant
Entrez Gene 19374 
UniGene Mm.4988
RefSeq NM_009020 
OMIM
CCDS CCDS16462 
HPRD
IMGT
MGI ID MGI:97849 
MGI Symbol Rag2
EMBL AK040375 AK089075 AL929569 AY011940 BC120548 BC125473 CH466519 M64796
GenPept AAB82302  AAG38683  AAI20549  AAI25474  BAC30576  BAC40737  CAM20887  EDL27654 
ImmGen Rag2 (murine) 
RNA Seq Atlas 19374