InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Rag2

Summary

InnateDB Gene

IDBG-193167.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rag2

Gene Name

recombination activating gene 2

Synonyms

Rag-2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000032864

Encoded Proteins

IDBP-193169

recombination activating gene 2

IDBP-258576

recombination activating gene 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000175097:
This gene encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:101624718-101632529

Strand

Forward strand

Band

Transcripts

ENSMUST00000044031	ENSMUSP00000038204
ENSMUST00000111227	ENSMUSP00000106858

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	6 [view]
Protein-DNA	7 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding
GO:0008270	zinc ion binding
GO:0035064	methylated histone binding
GO:0035091	phosphatidylinositol binding
GO:0043325	phosphatidylinositol-3,4-bisphosphate binding
GO:0080025	phosphatidylinositol-3,5-bisphosphate binding

Biological Process

GO:0002326	B cell lineage commitment
GO:0002331	pre-B cell allelic exclusion
GO:0002358	B cell homeostatic proliferation
GO:0002360	T cell lineage commitment
GO:0006310	DNA recombination
GO:0016568	chromatin modification
GO:0030183	B cell differentiation
GO:0030217	T cell differentiation
GO:0033077	T cell differentiation in thymus
GO:0033151	V(D)J recombination
GO:0046622	positive regulation of organ growth

Cellular Component

GO:0005634

nucleus

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000175097

View Gene Order

ENSBTAG00000031309

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu05340

Primary immunodeficiency pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa05340

Primary immunodeficiency pathway

INOH

PID NCI

cmyb_pathway

C-MYB transcription factor network

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.4988

RefSeq

NM_009020

OMIM

CCDS

CCDS16462

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas