Version 5.4
Mus musculus Gene: Znrf1
Summary
InnateDB Gene IDBG-193416.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Znrf1
Gene Name zinc and ring finger 1
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000033545
Encoded Proteins
IDBP-193418
zinc and ring finger 1
IDBP-622748
zinc and ring finger 1
IDBP-622753
zinc and ring finger 1
IDBP-622754
zinc and ring finger 1
IDBP-622756
zinc and ring finger 1
IDBP-622757
zinc and ring finger 1
IDBP-622759
zinc and ring finger 1
IDBP-622762
zinc and ring finger 1
IDBP-622763
zinc and ring finger 1
IDBP-622767
zinc and ring finger 1
IDBP-622772
zinc and ring finger 1
IDBP-622773
zinc and ring finger 1
IDBP-622774
zinc and ring finger 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000186187:
This gene encodes an E3 ubiquitin-protein ligase that plays a role in neural-cell differentiation. Overexpression of this gene causes neurite-like elongation. The encoded protein contains both a zinc finger and a RING finger motif and is localized in the endosome/lysosome compartment, indicating that it may be involved in ubiquitin-mediated protein modification, and in synaptic vessicle membranes in neurons. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:111536097-111626030
Strand Forward strand
Band E1
Transcripts
ENSMUST00000095176 ENSMUSP00000092799
ENSMUST00000172856 ENSMUSP00000133309
ENSMUST00000173506 ENSMUSP00000133993
ENSMUST00000173726 ENSMUSP00000133472
ENSMUST00000174376 ENSMUSP00000133455
ENSMUST00000174454 ENSMUSP00000133519
ENSMUST00000174333 ENSMUSP00000134634
ENSMUST00000173481
ENSMUST00000173781 ENSMUSP00000134232
ENSMUST00000173692
ENSMUST00000173922 ENSMUSP00000134369
ENSMUST00000173819 ENSMUSP00000133361
ENSMUST00000171182 ENSMUSP00000127956
ENSMUST00000168428 ENSMUSP00000126684
ENSMUST00000166859 ENSMUSP00000132939
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0007010 cytoskeleton organization
GO:0016567 protein ubiquitination
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936 protein K48-linked ubiquitination
Cellular Component
GO:0005764 lysosome
GO:0005768 endosome
GO:0005829 cytosol
GO:0016020 membrane
GO:0030054 cell junction
GO:0030672 synaptic vesicle membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000186187
View Gene Order
ENSBTAG00000034689
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.401830 Mm.470930 Mm.486362
RefSeq NM_001168621 NM_001168622 NM_001168623 NM_133206 XM_006530733 XM_006530734
OMIM
CCDS CCDS22676 CCDS52673 CCDS52674
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca