Version 5.4
Bos taurus Gene: ZNRF1
Summary
InnateDB Gene IDBG-629012.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZNRF1
Gene Name E3 ubiquitin-protein ligase ZNRF1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000034689
Encoded Proteins
IDBP-680394
zinc and ring finger 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000186187:
This gene encodes an E3 ubiquitin-protein ligase that plays a role in neural-cell differentiation. Overexpression of this gene causes neurite-like elongation. The encoded protein contains both a zinc finger and a RING finger motif and is localized in the endosome/lysosome compartment, indicating that it may be involved in ubiquitin-mediated protein modification, and in synaptic vessicle membranes in neurons. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:2396335-2482363
Strand Forward strand
Band
Transcripts
ENSBTAT00000049126 ENSBTAP00000046062
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0016567 protein ubiquitination
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936 protein K48-linked ubiquitination
Cellular Component
GO:0005764 lysosome
GO:0005768 endosome
GO:0005829 cytosol
GO:0016020 membrane
GO:0030054 cell junction
GO:0030672 synaptic vesicle membrane
GO:0031410 cytoplasmic vesicle
GO:0045202 synapse
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000186187
View Gene Order
ENSMUSG00000033545
View Gene Order
Cross-References
SwissProt F1MM41
TrEMBL
UniProt Splice Variant
Entrez Gene 509076
UniGene Bt.62231
RefSeq NM_001192210
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02045987
GenPept
RNA Seq Atlas 509076

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca