InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Khsrp

Summary

InnateDB Gene

IDBG-193424.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Khsrp

Gene Name

KH-type splicing regulatory protein

Synonyms

6330409F21Rik; Fbp2; Fubp2; Ksrp

Species

Mus musculus

Ensembl Gene

ENSMUSG00000007670

Encoded Proteins

IDBP-193426

KH-type splicing regulatory protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21690298

Khsrp directly interacts with AU-rich elements in the 3' UTR of Ifn mRNA to negatively regulate the transcript levels. Khsrp deficient mouse embryonic fibroblast produced higher levels of Ifna4 and Ifnb mRNAs in response to viral infections as a result of decreased mRNA decay.

InnateDB Annotation from Orthologs

Summary

PMID 21690298

[Homo sapiens] KHSRP directly interacts with AU-rich elements in the 3' UTR of IFN mRNA to negatively regulate the transcript levels. Khsrp deficient mouse embryonic fibroblast produced higher levels of Ifna4 and Ifnb mRNAs in response to viral infections as a result of decreased mRNA decay.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000088247:
The KHSRP gene encodes a multifunctional RNA-binding protein implicated in a variety of cellular processes, including transcription, alternative pre-mRNA splicing, and mRNA localization (Min et al., 1997 [PubMed 9136930]; Gherzi et al., 2004 [PubMed 15175153]).[supplied by OMIM, Apr 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:57021058-57031507

Strand

Reverse strand

Band

Transcripts

ENSMUST00000007814

ENSMUSP00000007814

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 52 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	3 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	52 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003723	RNA binding
GO:0003729	mRNA binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006397	mRNA processing
GO:0006402	mRNA catabolic process
GO:0008380	RNA splicing
GO:0045087	innate immune response (InnateDB)
GO:0051028	mRNA transport
GO:2000628	regulation of miRNA metabolic process