InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Khsrp

Summary

InnateDB Protein

IDBP-193426.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Khsrp

Protein Name

KH-type splicing regulatory protein

Synonyms

6330409F21Rik; Fbp2; Fubp2; Ksrp;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000007814

InnateDB Gene

IDBG-193424 (Khsrp)

Protein Structure

UniProt Annotation

Function

Binds to the dendritic targeting element and may play a role in mRNA trafficking. Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=A small proportion is also found in the cytoplasm of neuronal cell bodies and dendrites. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 52 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	3 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	52 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003723	RNA binding
GO:0003729	mRNA binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006397	mRNA processing
GO:0006402	mRNA catabolic process
GO:0008380	RNA splicing
GO:0045087	innate immune response (InnateDB)
GO:0051028	mRNA transport
GO:2000628	regulation of miRNA metabolic process