Version 5.4
Mus musculus Gene: Tnfsf9
Summary
InnateDB Gene IDBG-193693.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tnfsf9
Gene Name tumor necrosis factor (ligand) superfamily, member 9
Synonyms 4-1BB-L; 4-1BBL; AI848817; Cd137l; Ly63l
Species Mus musculus
Ensembl Gene ENSMUSG00000035678
Encoded Proteins
IDBP-193695
tumor necrosis factor (ligand) superfamily, member 9
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21747409
The expression of ligand-receptor pair Tnfsf9-Tnfrsf9 on monocytes and NK cells is induced by Mycobacterium tuberculosis. Blockage of the Tnfrsf9 pathway enhanced the level of Ifng and Tnfa producing lymphocytes against the pathogen. (Demonstrated in human)
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 17:57105385-57107757
Strand Forward strand
Band D
Transcripts
ENSMUST00000039490 ENSMUSP00000040412
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005125 cytokine activity
GO:0005164 tumor necrosis factor receptor binding
GO:0005515 protein binding
GO:0032813 tumor necrosis factor receptor superfamily binding
Biological Process
GO:0006955 immune response
GO:0032729 positive regulation of interferon-gamma production
GO:0032735 positive regulation of interleukin-12 production
GO:0032755 positive regulation of interleukin-6 production
GO:0042104 positive regulation of activated T cell proliferation
GO:0042127 regulation of cell proliferation
GO:0043011 myeloid dendritic cell differentiation
GO:0045087 innate immune response (InnateDB)
GO:0045585 positive regulation of cytotoxic T cell differentiation
Cellular Component
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
mmu04060
Cytokine-cytokine receptor interaction pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.41171
RefSeq NM_009404
OMIM
CCDS CCDS28926
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca