InnateDB Protein
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IDBP-193695.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Tnfsf9
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Protein Name
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tumor necrosis factor (ligand) superfamily, member 9
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Synonyms
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4-1BB-L; 4-1BBL; AI848817; Cd137l; Ly63l;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000040412
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InnateDB Gene
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IDBG-193693 (Tnfsf9)
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Protein Structure
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Function |
Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages.
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Subcellular Localization |
Membrane; Single-pass type II membrane protein.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0006955
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immune response
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GO:0032729
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positive regulation of interferon-gamma production
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GO:0032735
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positive regulation of interleukin-12 production
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GO:0032755
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positive regulation of interleukin-6 production
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GO:0042104
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positive regulation of activated T cell proliferation
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GO:0042127
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regulation of cell proliferation
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GO:0043011
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myeloid dendritic cell differentiation
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GO:0045087
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innate immune response (InnateDB)
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GO:0045585
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positive regulation of cytotoxic T cell differentiation
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Cellular Component |
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PDB ID |
MGI:1101058
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InterPro |
IPR006052
Tumour necrosis factor domain
IPR008983
Tumour necrosis factor-like domain
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PFAM |
PF00229
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PRINTS |
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PIRSF |
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SMART |
SM00207
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TIGRFAMs |
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Modification |
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SwissProt |
P41274
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PhosphoSite |
PhosphoSite-P41274
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TrEMBL |
Q3U1Z9
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UniProt Splice Variant |
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Entrez Gene |
21950
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UniGene |
Mm.41171
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RefSeq |
NP_033430
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MGI ID |
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MGI Symbol |
Tnfsf9
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OMIM |
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CCDS |
CCDS28926
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HPRD |
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IMGT |
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EMBL |
AK155610
BC138767
BC138770
CH466537
L15435
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GenPept |
AAA39435
AAI38768
AAI38771
BAE33344
EDL38238
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