Version 5.4
Homo sapiens Gene: OTOA
Summary
InnateDB Gene IDBG-19380.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol OTOA
Gene Name otoancorin
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000155719
Encoded Proteins
IDBP-19382
otoancorin
IDBP-19386
otoancorin
IDBP-19388
otoancorin
IDBP-19390
otoancorin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is specifically expressed in the inner ear, and is located at the interface between the apical surface of the inner ear sensory epithelia and their overlying acellular gels. It is prposed that this protein is involved in the attachment of the inner ear acellular gels to the apical surface of the underlying nonsensory cells. Mutations in this gene are associated with autosomal recessive deafness type 22 (DFNB22). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:21678514-21760729
Strand Forward strand
Band p12.2
Transcripts
ENST00000286149 ENSP00000286149
ENST00000388958 ENSP00000373610
ENST00000388956 ENSP00000373608
ENST00000388957 ENSP00000373609
ENST00000563506
ENST00000569064
ENST00000563871
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0007160 cell-matrix adhesion
GO:0007605 sensory perception of sound
GO:0019226 transmission of nerve impulse
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0016324 apical plasma membrane
GO:0031225 anchored component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000034990
View Gene Order
ENSBTAG00000018870
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.408336
RefSeq NM_001161683 NM_144672 NM_170664
HUGO
OMIM
CCDS CCDS10600 CCDS32403 CCDS53994
HPRD 06126
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca