InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cat

Summary

InnateDB Gene

IDBG-193911.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cat

Gene Name

catalase

Synonyms

2210418N07; Cas-1; Cas1; Cs-1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000027187

Encoded Proteins

IDBP-193913

catalase

IDBP-258696

catalase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000121691:
This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene. [provided by RefSeq, Oct 2009]
This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer\'s disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene. [provided by RefSeq, Oct 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:103453849-103485160

Strand

Reverse strand

Band

Transcripts

ENSMUST00000028610	ENSMUSP00000028610
ENSMUST00000111168	ENSMUSP00000106798

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004046	aminoacylase activity
GO:0004096	catalase activity
GO:0005102	receptor binding
GO:0016209	antioxidant activity
GO:0016684	oxidoreductase activity, acting on peroxide as acceptor
GO:0019899	enzyme binding
GO:0020037	heme binding
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding
GO:0050661	NADP binding

Biological Process

GO:0000302	response to reactive oxygen species
GO:0001649	osteoblast differentiation
GO:0001657	ureteric bud development
GO:0001666	response to hypoxia
GO:0001822	kidney development
GO:0006641	triglyceride metabolic process
GO:0006979	response to oxidative stress
GO:0007568	aging
GO:0008203	cholesterol metabolic process
GO:0009060	aerobic respiration
GO:0009650	UV protection
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
GO:0020027	hemoglobin metabolic process
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0033197	response to vitamin E
GO:0042697	menopause
GO:0042744	hydrogen peroxide catabolic process
GO:0043066	negative regulation of apoptotic process
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051262	protein tetramerization
GO:0051289	protein homotetramerization
GO:0051781	positive regulation of cell division
GO:0055093	response to hyperoxia
GO:0055114	oxidation-reduction process
GO:0071363	cellular response to growth factor stimulus

Cellular Component

GO:0005739	mitochondrion
GO:0005758	mitochondrial intermembrane space
GO:0005764	lysosome
GO:0005777	peroxisome
GO:0005778	peroxisomal membrane
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome