Version 5.4
Mus musculus Gene: Sesn2
Summary
InnateDB Gene IDBG-194024.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sesn2
Gene Name sestrin 2
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000028893
Encoded Proteins
IDBP-194026
sestrin 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000130766:
This gene encodes a member of the sestrin family of PA26-related proteins. The encoded protein may function in the regulation of cell growth and survival. This protein may be involved in cellular response to different stress conditions. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:132492032-132510501
Strand Reverse strand
Band D2.3
Transcripts
ENSMUST00000030724 ENSMUSP00000030724
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0001932 regulation of protein phosphorylation
GO:0006635 fatty acid beta-oxidation
GO:0006914 autophagy
GO:0007005 mitochondrion organization
GO:0009749 response to glucose
GO:0032042 mitochondrial DNA metabolic process
GO:0032868 response to insulin
GO:0042593 glucose homeostasis
GO:0043491 protein kinase B signaling
GO:0046323 glucose import
GO:0070328 triglyceride homeostasis
GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis
GO:1901031 regulation of response to reactive oxygen species
GO:2000479 regulation of cAMP-dependent protein kinase activity
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000130766
View Gene Order
ENSBTAG00000002363
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04115
p53 signaling pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04115
p53 signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt P58043
TrEMBL
UniProt Splice Variant
Entrez Gene 230784
UniGene Mm.400799
RefSeq NM_144907
OMIM
CCDS CCDS18726
HPRD
IMGT
MGI ID MGI:2651874
MGI Symbol Sesn2
EMBL BC005672
GenPept AAH05672
RNA Seq Atlas 230784

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca