InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Lrp6

Summary

InnateDB Gene

IDBG-194033.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lrp6

Gene Name

low density lipoprotein receptor-related protein 6

Synonyms

C030016K15Rik; Cd; Gw; ska; ska26; skax26

Species

Mus musculus

Ensembl Gene

ENSMUSG00000030201

Encoded Proteins

IDBP-194035

low density lipoprotein receptor-related protein 6

IDBP-257031

low density lipoprotein receptor-related protein 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000070018:
This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.[provided by RefSeq, Dec 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:134446476-134566965

Strand

Reverse strand

Band

Transcripts

ENSMUST00000032322	ENSMUSP00000032322
ENSMUST00000111950	ENSMUSP00000107581
ENSMUST00000126836

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	3 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005041	low-density lipoprotein receptor activity
GO:0005102	receptor binding
GO:0005109	frizzled binding
GO:0005515	protein binding
GO:0015026	coreceptor activity
GO:0017147	Wnt-protein binding
GO:0019210	kinase inhibitor activity
GO:0019534	toxin transporter activity
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0042813	Wnt-activated receptor activity
GO:0071936	coreceptor activity involved in Wnt receptor signaling pathway

Biological Process

GO:0001702	gastrulation with mouth forming second
GO:0001756	somitogenesis
GO:0001843	neural tube closure
GO:0001933	negative regulation of protein phosphorylation
GO:0001947	heart looping
GO:0002053	positive regulation of mesenchymal cell proliferation
GO:0003344	pericardium morphogenesis
GO:0003401	axis elongation
GO:0006355	regulation of transcription, DNA-templated
GO:0006469	negative regulation of protein kinase activity
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007268	synaptic transmission
GO:0009880	embryonic pattern specification
GO:0009950	dorsal/ventral axis specification
GO:0009952	anterior/posterior pattern specification
GO:0014029	neural crest formation
GO:0014033	neural crest cell differentiation
GO:0016055	Wnt signaling pathway
GO:0016337	single organismal cell-cell adhesion
GO:0021587	cerebellum morphogenesis
GO:0021794	thalamus development
GO:0021795	cerebral cortex cell migration
GO:0021861	forebrain radial glial cell differentiation
GO:0021872	forebrain generation of neurons
GO:0021874	Wnt receptor signaling pathway involved in forebrain neuroblast division
GO:0021915	neural tube development
GO:0021943	formation of radial glial scaffolds
GO:0021987	cerebral cortex development
GO:0030178	negative regulation of Wnt signaling pathway
GO:0030326	embryonic limb morphogenesis
GO:0030900	forebrain development
GO:0030901	midbrain development
GO:0030917	midbrain-hindbrain boundary development
GO:0034392	negative regulation of smooth muscle cell apoptotic process
GO:0035108	limb morphogenesis
GO:0035115	embryonic forelimb morphogenesis
GO:0035116	embryonic hindlimb morphogenesis
GO:0035261	external genitalia morphogenesis
GO:0036342	post-anal tail morphogenesis
GO:0042074	cell migration involved in gastrulation
GO:0042127	regulation of cell proliferation
GO:0042475	odontogenesis of dentin-containing tooth
GO:0042733	embryonic digit morphogenesis
GO:0043065	positive regulation of apoptotic process
GO:0043434	response to peptide hormone
GO:0044332	Wnt signaling pathway involved in dorsal/ventral axis specification
GO:0045599	negative regulation of fat cell differentiation
GO:0045778	positive regulation of ossification
GO:0045780	positive regulation of bone resorption
GO:0045787	positive regulation of cell cycle
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046849	bone remodeling
GO:0048596	embryonic camera-type eye morphogenesis
GO:0048699	generation of neurons
GO:0048705	skeletal system morphogenesis
GO:0050680	negative regulation of epithelial cell proliferation
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051593	response to folic acid
GO:0060021	palate development
GO:0060026	convergent extension
GO:0060042	retina morphogenesis in camera-type eye
GO:0060059	embryonic retina morphogenesis in camera-type eye
GO:0060070	canonical Wnt signaling pathway
GO:0060284	regulation of cell development
GO:0060325	face morphogenesis
GO:0060444	branching involved in mammary gland duct morphogenesis
GO:0060535	trachea cartilage morphogenesis
GO:0060596	mammary placode formation
GO:0060603	mammary gland duct morphogenesis
GO:0061310	canonical Wnt receptor signaling pathway involved in cardiac neural crest cell differentiation involved in heart development
GO:0061324	canonical Wnt receptor signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation
GO:0071397	cellular response to cholesterol
GO:0071542	dopaminergic neuron differentiation
GO:0071901	negative regulation of protein serine/threonine kinase activity
GO:0090009	primitive streak formation
GO:0090118	receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport
GO:0090244	Wnt signaling pathway involved in somitogenesis
GO:0090245	axis elongation involved in somitogenesis
GO:0090263	positive regulation of canonical Wnt signaling pathway
GO:1901998	toxin transport
GO:2000051	negative regulation of non-canonical Wnt signaling pathway
GO:2000055	positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification
GO:2000149	negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis
GO:2000151	negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis
GO:2000162	negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis
GO:2000164	negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis
GO:2000166	negative regulation of planar cell polarity pathway involved in pericardium morphogenesis
GO:2000168	negative regulation of planar cell polarity pathway involved in neural tube closure

Cellular Component

GO:0005769	early endosome
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0005901	caveola
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031410	cytoplasmic vesicle
GO:0043025	neuronal cell body
GO:0043235	receptor complex
GO:0045202	synapse