Version 5.4
Mus musculus Protein: Lrp6
Summary
InnateDB Protein IDBP-257031.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol Lrp6
Protein Name low density lipoprotein receptor-related protein 6
Synonyms C030016K15Rik; Cd; Gw; ska; ska26; skax26;
Species Mus musculus
Ensembl Protein ENSMUSP00000107581
InnateDB Gene IDBG-194033 (Lrp6)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.
Experimentally validated
Total 19 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 3 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 21 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005041 low-density lipoprotein receptor activity
GO:0005109 frizzled binding
GO:0005515 protein binding
GO:0015026 coreceptor activity
GO:0017147 Wnt-protein binding
GO:0019210 kinase inhibitor activity
GO:0019534 toxin transporter activity
GO:0042803 protein homodimerization activity
GO:0042813 Wnt-activated receptor activity
GO:0071936 coreceptor activity involved in Wnt receptor signaling pathway
Biological Process
GO:0001702 gastrulation with mouth forming second
GO:0001756 somitogenesis
GO:0001843 neural tube closure
GO:0001947 heart looping
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0003344 pericardium morphogenesis
GO:0003401 axis elongation
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007268 synaptic transmission
GO:0009880 embryonic pattern specification
GO:0009950 dorsal/ventral axis specification
GO:0009952 anterior/posterior pattern specification
GO:0014029 neural crest formation
GO:0016055 Wnt signaling pathway
GO:0016337 single organismal cell-cell adhesion
GO:0021587 cerebellum morphogenesis
GO:0021794 thalamus development
GO:0021795 cerebral cortex cell migration
GO:0021861 forebrain radial glial cell differentiation
GO:0021872 forebrain generation of neurons
GO:0021874 Wnt receptor signaling pathway involved in forebrain neuroblast division
GO:0021915 neural tube development
GO:0021943 formation of radial glial scaffolds
GO:0021987 cerebral cortex development
GO:0030178 negative regulation of Wnt signaling pathway
GO:0030326 embryonic limb morphogenesis
GO:0030900 forebrain development
GO:0030901 midbrain development
GO:0030917 midbrain-hindbrain boundary development
GO:0034392 negative regulation of smooth muscle cell apoptotic process
GO:0035108 limb morphogenesis
GO:0035115 embryonic forelimb morphogenesis
GO:0035116 embryonic hindlimb morphogenesis
GO:0035261 external genitalia morphogenesis
GO:0036342 post-anal tail morphogenesis
GO:0042074 cell migration involved in gastrulation
GO:0042127 regulation of cell proliferation
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042733 embryonic digit morphogenesis
GO:0043065 positive regulation of apoptotic process
GO:0043434 response to peptide hormone
GO:0044332 Wnt signaling pathway involved in dorsal/ventral axis specification
GO:0045599 negative regulation of fat cell differentiation
GO:0045778 positive regulation of ossification
GO:0045780 positive regulation of bone resorption
GO:0045787 positive regulation of cell cycle
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046849 bone remodeling
GO:0048596 embryonic camera-type eye morphogenesis
GO:0048699 generation of neurons
GO:0048705 skeletal system morphogenesis
GO:0050680 negative regulation of epithelial cell proliferation
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051593 response to folic acid
GO:0060021 palate development
GO:0060026 convergent extension
GO:0060042 retina morphogenesis in camera-type eye
GO:0060059 embryonic retina morphogenesis in camera-type eye
GO:0060070 canonical Wnt signaling pathway
GO:0060284 regulation of cell development
GO:0060325 face morphogenesis
GO:0060444 branching involved in mammary gland duct morphogenesis
GO:0060535 trachea cartilage morphogenesis
GO:0060596 mammary placode formation
GO:0060603 mammary gland duct morphogenesis
GO:0061310 canonical Wnt receptor signaling pathway involved in cardiac neural crest cell differentiation involved in heart development
GO:0061324 canonical Wnt receptor signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation
GO:0071397 cellular response to cholesterol
GO:0071542 dopaminergic neuron differentiation
GO:0071901 negative regulation of protein serine/threonine kinase activity
GO:0090009 primitive streak formation
GO:0090118 receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport
GO:0090244 Wnt signaling pathway involved in somitogenesis
GO:0090245 axis elongation involved in somitogenesis
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:1901998 toxin transport
GO:2000051 negative regulation of non-canonical Wnt signaling pathway
GO:2000055 positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification
GO:2000149 negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis
GO:2000151 negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis
GO:2000162 negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis
GO:2000164 negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis
GO:2000166 negative regulation of planar cell polarity pathway involved in pericardium morphogenesis
GO:2000168 negative regulation of planar cell polarity pathway involved in neural tube closure
Cellular Component
GO:0005769 early endosome
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005901 caveola
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031410 cytoplasmic vesicle
GO:0043025 neuronal cell body
GO:0043235 receptor complex
GO:0045202 synapse
Protein Structure and Domains
PDB ID MGI:1298218
InterPro IPR000033 LDLR class B repeat
IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
PFAM PF00058
PF00057
PRINTS PR00261
PIRSF
SMART SM00135
SM00192
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q3TS86
UniProt Splice Variant
Entrez Gene 16974
UniGene Mm.410062
RefSeq
MGI ID
MGI Symbol Lrp6
OMIM
CCDS
HPRD
IMGT
EMBL AC155838 AC163198 AK162203
GenPept BAE36789

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca