InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Agap2

Summary

InnateDB Gene

IDBG-194143.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Agap2

Gene Name

ArfGAP with GTPase domain, ankyrin repeat and PH domain 2

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000025422

Encoded Proteins

IDBP-194145

ArfGAP with GTPase domain, ankyrin repeat and PH domain 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000135439:
The protein encoded by this gene belongs to the centaurin gamma-like family. It mediates anti-apoptotic effects of nerve growth factor by activating nuclear phosphoinositide 3-kinase. It is overexpressed in cancer cells, and promotes cancer cell invasion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:127078907-127093169

Strand

Forward strand

Band

Transcripts

ENSMUST00000039259

ENSMUSP00000043466

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0008060	ARF GTPase activator activity
GO:0008270	zinc ion binding
GO:0019901	protein kinase binding
GO:0030295	protein kinase activator activity

Biological Process

GO:0006184	GTP catabolic process
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
GO:0015031	protein transport
GO:0032312	regulation of ARF GTPase activity
GO:0033601	positive regulation of mammary gland epithelial cell proliferation
GO:0043066	negative regulation of apoptotic process
GO:0043524	negative regulation of neuron apoptotic process
GO:0043547	positive regulation of GTPase activity
GO:0045860	positive regulation of protein kinase activity
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046427	positive regulation of JAK-STAT cascade
GO:0060749	mammary gland alveolus development
GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005739	mitochondrion
GO:0016020	membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000135439

View Gene Order

ENSBTAG00000007156

Not yet available

Pathways

NETPATH

REACTOME

REACT_229826

Netrin-1 signaling pathway

REACT_261444

Axon guidance pathway

REACT_188576

Developmental Biology pathway

KEGG

mmu04144

Endocytosis pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_56

Prolactin pathway

REACTOME

REACT_22237

Netrin-1 signaling pathway

REACT_111045

Developmental Biology pathway

REACT_18266

Axon guidance pathway

KEGG

hsa04144

Endocytosis pathway

INOH

PID NCI

pi3kplctrkpathway

Trk receptor signaling mediated by PI3K and PLC-gamma

netrin_pathway

Netrin-mediated signaling events

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.336761

RefSeq

NM_001033263 XM_006513557 XM_006513561 XM_006513562

OMIM

CCDS

CCDS24228

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas